| 一种含有异氰酸酯功能基团单体的生物安全性初步研究 |
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| 引用本文： | 杨振宇,段龙彦,周唯,高婧,方明,陈吉华.一种含有异氰酸酯功能基团单体的生物安全性初步研究[J].实用口腔医学杂志,2022(1):13-17. |
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| 作者姓名： | 杨振宇 段龙彦 周唯 高婧 方明 陈吉华 |
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| 作者单位： | 军事口腔医学国家重点实验室 |
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| 基金项目： | 国家自然科学基金(编号:81720108011,81801009)。 |
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| 摘 要： | 目的:评价一种新型牙本质反应性单体的生物安全性.方法:用异佛尔酮二异氰酸酯(IPDI)和甲基丙烯酸羟乙酯(HEMA)为原料通过亲核加成反应合成目标单体,以ISO 10993标准,根据口腔环境特点,选择体内体外4种实验评价单体生物安全性.结果:该单体体外细胞毒性为Ⅰ级;对兔血的溶血率为3.6％;短期全身毒性试验显示对Ba...
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| 关 键 词： | 异氰酸酯 结构表征分析 生物安全性 |
Preliminary evaluation on the biological safety of a monomer containing isocyanate functional groups |
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| YANG Zhenyu,DUAN Longyan,ZHOU Wei,GAO Jing,FANG Ming,CHEN Jihua.Preliminary evaluation on the biological safety of a monomer containing isocyanate functional groups[J].Journal of Practical Stomatology,2022(1):13-17. |
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| Authors: | YANG Zhenyu DUAN Longyan ZHOU Wei GAO Jing FANG Ming CHEN Jihua |
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| Affiliation: | (State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Key Laboratory of Stomato logy,Department of Prosthodontics,School of Stomatology,The Fourth Military Medical University,Xi'an 710032,China) |
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| Abstract: | Objective:To evaluate the biological safety of a new dentin reactive monomer.Methods:The target monomer was synthesized from Isophorone diisocyanate(IPDI)and Hydroxyethyl methylacrylate(HEMA)by nucleophilic addition reaction.According to the standard of ISO 10993 and the characteristics of oral environment,4 in vitro and in vivo tests were used to evaluate the biological safety of the monomer.Results:In vitro cytotoxicity of the monomer was gradeⅠ.The hemolysis rate of the monomer to rabbit blood was 3.6%.Short-term systemic toxicity test showed that the monomer had no short-term systemic toxicity effect in Balb/C mice.No histological abnormality was found in oral mucosa stimulation test.Conclusion:The monomer may possesse biological safety. |
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| Keywords: | Isocyanate Structural characterization analysis Biological safety |
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