| 正交试验优选参菊洗剂的提取工艺 |
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| 引用本文： | 张广求,刘文,王树平,田祥学.正交试验优选参菊洗剂的提取工艺[J].中国医药导报,2014(14):99-101. |
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| 作者姓名： | 张广求 刘文 王树平 田祥学 |
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| 作者单位： | [1]湖北省黄冈市中心医院药剂科,湖北黄冈438000 [2]湖北省黄冈市食品药品监督检验中心,湖北黄冈438000 |
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| 基金项目： | 湖北省黄冈市科技计划项目（编号黄科字[2013]76号）. |
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| 摘 要： | 目的 优选参菊洗剂的提取工艺。方法 以苦参碱的含量为评价指标，按正交表L9（3^4）设计试验，考察加水量、浸泡时间、提取时间和提取次数4个因素。结果 提取时间对提取效果有显著影响，提取工艺的最佳参数为：加水量为8倍，浸泡时间为2h，提取时间为每次1．5h，提取次数为2次。结论 优选的提取工艺能较好地保证制剂的质量。
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| 关 键 词： | 正交试验 提取工艺 参菊洗剂 苦参碱 |
Optimization of the extraction technology of Shenju Lotion by orthogonal experiment |
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| ZHANG Guangqiu,LIU Wen,WANG Shupin,TIAN Xiangxue.Optimization of the extraction technology of Shenju Lotion by orthogonal experiment[J].China Medical Herald,2014(14):99-101. |
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| Authors: | ZHANG Guangqiu LIU Wen WANG Shupin TIAN Xiangxue |
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| Affiliation: | 1.Department of Pharmacy, Huanggang Central Hospital, Hubei Province, Huanggang 438000, China; 2.Huanggang Center for Food and Drug Control, Hubei Province, Huanggang 438000, China) |
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| Abstract: | Objective To optimize the extraction technology of Shenju Lotion. Methods The extraction technology of Shenju Lotion was optimized by L9（3^4） orthogonal test with matrine and the yield of extract as index, and amount of water added, time of soaking, duration of decoction and times of decoction as four factors. Results The time of decoction was the most important factor in the extraction process. The best extraction technology was adding 8 times of water, marinating for 2 h in advance, and the material should be decoeted twice with 1.5 h each time. Conclusion The extraction technology shows stabilization and feasibility and can be available for industrial production at large scale. |
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| Keywords: | Orthogonal experiment Extraction technology Shenju Lotion Matrine |
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