丁苯酞胶囊联合银杏达莫治疗老年急性脑梗死 120例效果观察

目的观察丁苯酞胶囊联合银杏达莫治疗老年急性脑梗死的效果和安全性。方法将2012年4月～2014年1月在中山市大涌医院住院的120例老年急性脑梗死患者随机分为观察组和对照组，各60例。观察组给予丁苯酞胶囊口服加银杏达莫静滴治疗，对照组给予血塞通静滴，疗程均为15d。收集治疗前后数据，观察比较两组临床疗效、神经功能缺损评分、血液学指标及不良反应情况。结果观察组总有效率（85．0％）高于对照组（68．3％），差异有统计学意义（P〈0．05）；治疗后两组神经功能缺损评分均有明显降低（P〈0．01），观察组神经功能缺损评分改善优于对照组（P〈0．05）；治疗后两组纤维蛋白原、D-二聚体、超敏C反应蛋白都有不同程度降低（均P〈0．05），观察组D一二聚体及超敏C反应蛋白改善作用明显优于对照组，差异有统计学意义（P〈0．05）；观察组及对照组治疗过程中未出现明显药物不良反应。结论联合应用丁苯酞胶囊和银杏达莫注射液治疗老年急性脑梗死有较好的临床效果及安全性。

Observation on Butylphthalide Capsule combined with Ginkgo Dipyri- dolum Injection in the treatment of 120 cases of elderly patients with a- cute cerebral infarction

Objective To observe the efficacy and safety of Butylphthalide Capsule combined with Ginkgo Dipyri- dolum Injection in the treatment of elderly patients with acute cerebral infarction. Methods 120 cases of elderly pa- tients with acute cerebral infarction admitted to Zhongshan Dachong Hospital from April 2012 to January 2014 were randomly divided into observation group and control group, with 60 cases in each group. The observation group was given Butylphthalide Capsule oral and Butylphthalide Capsule intravenous therapy, control group was treated with Xuesaitong Injection for intravenous drip, the course was 15 days. Data before and after treatment was collected, the clinical effects, NIHSS, haematological index and side effects of the two groups were observed and compared. Results The total effective rate of the observation group （85.0%） was higher than that of control group （68.3%）, the difference was statistically significant （P 〈 0.05）; the scores of NIHSS after treatment in the two groups were all decreased sig- nificantly （P 〈 0.01）, while the improvement of NIHSS in the observation group was better than the control group （P 〈 0.05）; after treatment, the fibrinogen, D-dimer, high-sensitivity C-reactive protein in the two groups were all de- creased （all P 〈 0.05）, while the improvement of D-dimer, high-sensitivity C-reactive protein in the observation group were significantly better than the control group, the differences were statistically significant （P 〈 0.05）; there were no obvious adverse drug reactions during the treatment in the observation group and control group. Conclusion The combined application of Butylphthalide Capsule combined with Ginkgo Dipyridolum Injection in the treatment of elderly patients with acute cerebral infarction has a better clinical efficacy and good safety.