富锗大麦苗对小鼠急性肝损伤的保护作用

目的：研究富锗大麦苗对四氯化碳(CCl4)所致小鼠急性肝损伤的保护作用。方法：建立CCl4 小鼠急性肝损伤动物模型，用不同剂量富锗大麦苗对小鼠灌胃，测定小鼠血清谷丙转氨酶(ALT)活性及免疫器官重量等指标，对其进行统计分析，并对小鼠肝脏进行组织切片观察。结果：富锗大麦苗低、中、高剂量组均能显著抑制CCl4所致急性肝损伤小鼠ALT 活性的升高(P ＜ 0.05，P ＜ 0.01)，明显改善肝组织损伤程度，并与其剂量呈正相关；富锗低、中、高剂量组具有明显提高肝脏指数(P ＜ 0.01)和脾脏指数的作用(P ＜ 0.01，P ＜ 0.05)。结论：富锗大麦苗对CCl4 所致小鼠急性肝损伤有明显的保护作用。

Hepatoprotective Function of Germanium-rich Barley Seedling in Mice with Acute Hepatic Injury

Objective: To investigate hepatoprotective effect of germanium-rich barley seedling (GRBS) in mice with acute hepatic injury induced by CCl4. Methods: Mice model with acute hepatic injury was established through induction of CCl4. The mice with acute hepatic injury were orally administered GRBS at different doses (low, medium and high-doses). ALT activity in serum and immune organs index were determined and pathological changes of livers were examined to evaluate the hepatoprotective effect of GRBS. Results: GRBS at three doses significantly inhibited ALT activity in serum (P < 0.05, P < 0.01) and promoted the recovery of hepatic tissue injury, which was in a dose-dependent mode. Moreover, GRBS also obviously improved liver index (P < 0.01) and spleen index (P < 0.01, P < 0.05). Conclusion: GRBS has hepatoprotective function for mice with acute hepatic injury induced by CCl4.