| 两面针抗宫颈癌谱-效关系研究 |
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| 引用本文： | 王宏虹,刘华钢,黄慧学,刘丽敏,申庆荣,曹利娟.两面针抗宫颈癌谱-效关系研究[J].中药药理与临床,2011(5):84-89. |
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| 作者姓名： | 王宏虹 刘华钢 黄慧学 刘丽敏 申庆荣 曹利娟 |
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| 作者单位： | 柳州市妇幼保健院;广西医科大学药学院;广西中医学院;广西壮族自治区人民医院;广西壮族自治区食品药品监督管理局; |
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| 基金项目： | 国家自然科学基金(项目批准号:30760302)两面针药材生物活性指纹图谱研究 |
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| 摘 要： | 目的:研究芸香科植物两面针HPLC指纹图谱与抗宫颈癌活性之间的关系。方法:对33批两面针药材进行HPLC分析,以人宫颈癌细胞株HeLa为药效模型,用MTT法测定各批次两面针药材的抗肿瘤活性,再通过多元线性回归法,建立两面针抗宫颈癌谱-效关系方程。结果:建立了两面针抗宫颈癌谱效关系方程,利用该方程对10批两面针药材进行抗宫颈癌活性预测,预测值与实际值的偏差率不超过10%,表明谱-效关系可用于预测两面针的抗宫颈癌作用。结论:两面针抗宫颈癌谱-效关系方程可反映抗肿瘤作用是两面针药材中多种成分协调、互补或制约相互作用的结果,谱-效关系研究为有效地控制两面针质量搭建新的平台。
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| 关 键 词： | 两面针 谱-效关系方程 宫颈癌 |
Studies on chromatogram-effect relation of Zanthoxylum nitidum(Roxb.)DC.on tumor cell line HeLa |
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| Wang Honghong,Liu Huagang,Huang Huixue,Liu Limin,Shen Qingrong,Cao Lijuan.Studies on chromatogram-effect relation of Zanthoxylum nitidum(Roxb.)DC.on tumor cell line HeLa[J].Pharmacology and Clinics of Chinese Materia Medica,2011(5):84-89. |
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| Authors: | Wang Honghong Liu Huagang Huang Huixue Liu Limin Shen Qingrong Cao Lijuan |
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| Affiliation: | Wang Honghong1,Liu Huagang2,Huang Huixue3,Liu Limin2,Shen Qingrong4,Cao Lijuan5 (1 Liuzhou Matemal and Child Health Hospital,Liuzhou 545001,2 School of Pharmaceutical Sciences,Guangxi Medical University,Nanning 530021,3 Guangxi Traditional Medical University,4 The Peoples Hospital of Guangxi Zhuang Autonomous Region,5 Guangxi Food and Drug Administration) |
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| Abstract: | Objective: To study the relationship between HPLC fingerprint chromatogram and inhibitory effect on anticancer activity of Zanthoxylum nitidum.Method: Zanthoxylum nitidum fingerprint was established,Tumor cell lines HeLa was chosen as efficacy model,the anticancer activity of 33 sources of Zanthoxylum nitidum extracts were determined using MTT method.Multiple linear regression was applied to construct a multivariate regression model.Results: The chromatogram-effect relationships on HeLa was established,10 Z... |
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| Keywords: | Zanthoxylum nitidum chromatogram-effect relationships HeLa |
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