| 哮宁口服液治疗小儿哮喘的临床前研究 |
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| 引用本文： | 张舒锦,程媛,李涓,郭蓉晓.哮宁口服液治疗小儿哮喘的临床前研究[J].中药药理与临床,2011(2):126-129. |
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| 作者姓名： | 张舒锦 程媛 李涓 郭蓉晓 |
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| 作者单位： | 成都中医药大学附属医院; |
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| 基金项目： | 四川省教委科研基金资助项目 |
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| 摘 要： | 目的:研究哮宁口服液的平喘、止咳、化痰和抗病毒作用,为临床治疗小儿哮喘提供依据。方法:采用离体气管螺旋条法观察哮宁口服液对气管平滑肌的松弛作用;采用氨水致小鼠咳嗽观察哮宁口服液对2min内咳嗽次数的影响;采用小鼠呼吸道酚红分泌实验观察哮宁口服液祛痰作用;采用体外抗病毒实验观察哮宁口服液对腺病毒3型(Adv3)、7型(Adv7)和呼吸道合胞病毒(RSV)的致细胞病变作用的影响。结果:离体气管螺旋条实验显示哮宁口服液20mg生药/ml、10mg生药/ml能使正常和组胺致痉的豚鼠气管螺旋条松驰;40g生药/kg和20g生药/kg能减少氨水导致小鼠咳嗽次数;增加小鼠呼吸道的酚红排泌量;体外抗病毒试验显示50mg生药/ml对3种病毒有明显抑制作用。结论:哮宁口服液具有平喘,止咳,化痰和抗病毒的药理作用。
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| 关 键 词： | 哮宁口服液 平喘 止咳 化痰 |
Preclinical study on the effect of Xiaoning Fluid treating athama in children |
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| Zhang Shujin,Cheng Yuan,Li Juan,Guo Rongxiao.Preclinical study on the effect of Xiaoning Fluid treating athama in children[J].Pharmacology and Clinics of Chinese Materia Medica,2011(2):126-129. |
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| Authors: | Zhang Shujin Cheng Yuan Li Juan Guo Rongxiao |
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| Affiliation: | Zhang Shujin,Cheng Yuan,Li Juan,Guo Rongxiao(Teaching Hospital of Chengdu University of TCM,Chengdu 610072) |
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| Abstract: | Aims:We investigated the antiasthmatic, antitussive, expectorant and antiviral effects of Xiaoning Fluid.Methods:In vitro tracheal spiral lines of guinea pig were used to observe the tracheaectasy effect of Xiaoning Fluid. Amuonia induced cough in mice was used to observe antitussive effect of Xiaoning Fluid. Phenol red secretion in mice was used to observe expectorant effect of Xiaoning Fluid. In vitro anti-viral experiment was used to observe the inhibition effect of Xiaoning Fluid on virus.Results:Xiaoni... |
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