HCPT联合FOLFOX4方案治疗晚期胃癌、大肠癌疗效观察

目的评价羟基喜树碱(HCPT)联合FOLFOX4方案治疗晚期胃癌、大肠癌的近期疗效和毒副反应。方法28例晚期消化道癌患者,先给予草酸铂(L-OHP)85mg/m2静脉点滴2h d1,亚叶酸钙(CF)200mg/m2静脉点滴2h d1~d2,随后5-氟尿嘧啶(5-FU)400mg/m2静脉推注,5-FU600mg/m2静脉点滴22h d1~d2,同时给予HCPT6 mg/m2静脉点滴3h d1~d3。2周重复,4周期后评价疗效。结果全组28例,其中完全缓解(CR)2例(7.1%),部分缓解(PR)16例(57.1%),稳定(SD)4例(14.3%),进展(PD)6例(21.4%)。总有效率(CR PR)64.3%。胃癌16例,11例有效,有效率68.8%。大肠癌12例,7例有效,有效率58.3%。毒副反应主要是恶心呕吐,白细胞减少,神经感觉毒性,无化疗相关死亡。结论HCPT联合FOLFOX4方案治疗晚期消化道癌疗效肯定,毒副反应能耐受。

Clinical study of hydroxycamptothecin(HCPT) combined with biweekly regimen of leucovorin,5-fluorouracil and oxaliplatin (FOLFOX4)in treatment of advanced gastrointestinal cancers

Objective To study the response and toxicity of the regimen of hydroxycamptothecin(HCPT) combined with biweekly regimen of leucovorin(CF),5-fluorouracil(5-FU) and oxaliplatin(L-OHP)(named FOLFOX4 regimen) in treat-ment of advanced gastrointestinal cancers.Mthods Twenty eight patients with advanced gastvointestinal cancer received chemotherapy of regimen L-OHP 80mg/m~2 2 hours iv on day1,CF 200 mg/m~2 2 hours iv on day 1to 2,followed by 5-FU 400 mg/m~2 iv and 600 mg/m~2 22 hours on day 1to 2.HCPT6 mg/m~2 iv 3 hours on day 1 to 3,two weeks as one cycle.Efficacy was evaluated after 4 cycles.Results Two patients achieved complete response(CR),16 patients partial response(PR),4 patients stable disease(SD),6 patients progression disease(PD).Overall response rate was 64.3%.Response rate was 68.8% in advanced gastric cancer.Response rate was 58.3% in advanced colorectal cancer.The major toxicity included nausea,vomiting,leucopenia and neuro-sensory.There were no any death during treatment.Conclusion This study shows that the regimen of HCPT combined with FOLFOX4 is effective and tolerable in advanced gastrointestinal cancer.