荔枝核粗皂甙降血糖作用的实验研究

目的 观察荔枝核粗皂甙对正常小鼠和糖尿病小鼠的降糖作用.方法 采用四氧嘧啶造糖尿病小鼠模型,荔枝核粗皂甙作治疗组、优降糖作阳性对照,生理盐水作阴性对照,连续给小鼠灌胃3 w后,测定正常小鼠和糖尿病小鼠空腹血糖值,比较降血糖的效果.结果 荔枝核粗皂甙对正常和糖尿病小鼠的降糖率分别为16.74%和59.57%,其降糖效力与正常组、模型组及优降糖组比较均有显著性差异(P＜0.05或0.01).结论 荔枝核总皂甙能降低正常和糖尿病小鼠的血糖.在本实验剂量下,荔枝核总皂甙降血糖作用效力显著优于优降糖.

Study on the hypoglycemic activity of saponin extracted from litchi seed

Objective To study the hypoglycemic activity of saponin extracted from litchi seed in diabetic and normal mice.Methods The diabetic mice model was made by injection of tetraoxypyrimidine.The diabetic mice were divided into three groups,the experimental group treated with the extracted saponin,the positive control group with dimethyldiguanide and the negative control group with normal saline.The mice in different groups were given different agents by continuous intragastric administration.After three weeks,the fasting blood sugar levels of the mice in different groups were detected.Results The hypoglycemic rate of the saponin on the normal and diabetic mice were 16.74% and 59.57% respectively.The hypoglycemic activity was stronger in the experimental group than that in the normal control group,negative control group and dimethyldiguanide group(P<0.05,0.01).Conclusion The saponin had the(hypoglycemic) activity on both the normal and diabetic mice,and the activity is stronger in the experimental group than that in the dimethyldiguanide group.