肠漏的机制及临床意义

肠上皮细胞及细胞间连接的完整性在防止肠腔内的有害物质进入体内方面发挥着重要作用。肠漏是指肠道机械屏障功能受损，肠上皮细胞间的细胞旁路途径异常开放，导致肠道通透性升高。肠漏被宣传为可引发多种非肠道疾病及临床症状，严重威胁着人类健康，但这种说法缺乏临床研究数据支持，夸大了肠漏在疾病发生、发展中的作用。因此如何客观看待肠漏与疾病的关系，有助于临床医生诊断和治疗肠道通透性升高所致的疾病。本综述将从肠道机械屏障与肠道通透性的关系、肠道通透性的检测方法、肠道通透性与疾病的关系等方面论述肠漏的机制及临床意义。

Leaky gut:mechanisms and clinical implications

A contiguous layer of cells as well as the junctions that seal the paracellular space play a fundamental function to separate luminal harmful contents from the interstitium.Leaky gut resulted from impaired mechanical barrier and dysfunctional paracellular pathway,leading to increased intestinal permeability.Leaky gut has been proposed to be associated with a number of disease states,but there is a lack of valid clinical data supporting such proposal.Therefore,it is important to provide a balanced view of the association between leaky gut and diseases to facilitate the diagnosis and treatment of disease associated with increased intestinal permeability.This review summarizes the mechanism and clinical significance of leaky gut from aspects including the relationship between mechanical intestinal barrier and intestinal permeability,measurement of intestinal permeability,and intestinal permeability in disease states.