| 主动脉夹层分子机制的研究进展 |
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| 引用本文： | 黄毕,杨艳敏,樊晓寒.主动脉夹层分子机制的研究进展[J].中国分子心脏病学杂志,2014(5):1103-1105. |
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| 作者姓名： | 黄毕 杨艳敏 樊晓寒 |
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| 作者单位： | 中国医学科学院北京协和医学院阜外心血管病医院心内科,北京市100037 |
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| 基金项目： | 国家自然科学基金（81170286） |
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| 摘 要： | 主动脉夹层是致死性很高的大血管疾病,其典型的组织学特征是主动脉中层退行性变。由于对主动脉壁退行性变的分子机制尚未阐明,目前尚缺乏有效预防主动脉夹层形成、进展和破裂的措施。近年来由于分子生物学和基因敲除动物的广泛应用,使主动脉夹层的分子机制取得较大进展。本文就近年来主动脉夹层分子机制的进展作简要综述。
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| 关 键 词： | 主动脉夹层 退行性变 分子机制 |
Review of the Molecular and Cellular Mechanisms of Aortic Dissection |
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| HUANG Bi,YANG Yan-min,FAN Xiao-han.Review of the Molecular and Cellular Mechanisms of Aortic Dissection[J].Molecular Cardiology of China,2014(5):1103-1105. |
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| Authors: | HUANG Bi YANG Yan-min FAN Xiao-han |
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| Affiliation: | . (Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.) |
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| Abstract: | Aortic dissection （AD） is a highly lethal vascular disease. The key histopathologic feature of AD is medial degeneration. Currently, dissection formation, progression, and rupture cannot be reliably predicted and prevented because the molecular mechanisms of aortic wall degeneration are poorly understood. Recently, the molecular mechanism of AD has made great progress due to the widespread use of molecular biology and gene knockout models. This article reviews the recent literature of molecular mechanism of AD. |
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| Keywords: | Aortic Dissection Degeneration Molecular Mechanism |
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