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正交试验优选黄连散中葛根等成分的提取工艺
引用本文:陈礼明,刘圣,唐丽琴,李矗.正交试验优选黄连散中葛根等成分的提取工艺[J].中国药房,2006,17(6):415-417.
作者姓名:陈礼明  刘圣  唐丽琴  李矗
作者单位:安徽省立医院药剂科,合肥市,230001
摘    要:目的:筛选黄连散中葛根、麦冬、枇杷叶的最佳提取工艺。方法:采用正交设计试验,以葛根素总量为指标,考察溶剂浓度、溶剂用量倍数、提取时间、提取次数4种因素对提取结果的影响。结果:最佳提取工艺为60%乙醇、8倍量、提取3次、每次60min。结论:该工艺所得浸膏得率和葛根素含量均较高,稳定、重现性好,可为黄连散的生产提供参考数据。

关 键 词:黄连散  正交试验  葛根素  提取工艺
文章编号:1001-0408(2006)06-0415-03
收稿时间:07 1 2005 12:00AM
修稿时间:11 1 2005 12:00AM

Optimization of Extraction Technology for Pueraria and Other Active Component in Huanglian Powder with Orthogonal Test
CHEN Liming,LIU Sheng,TANG Liqin,LI Chu.Optimization of Extraction Technology for Pueraria and Other Active Component in Huanglian Powder with Orthogonal Test[J].China Pharmacy,2006,17(6):415-417.
Authors:CHEN Liming  LIU Sheng  TANG Liqin  LI Chu
Affiliation:Dept. of Pharmacy, Anhui Provincial Hospital, Hefei 230001, China
Abstract:OBJECTIVE: To optimize the extraction technology of pueraria, ophiopogonis, and loquat leaf. METHODS: Orthogonal test was carried out. The influence of concentration of solvent, the dosage of solvent, time length of extraction, and frequency of extraction on extraction results were investigated by using the content of pueraria as index. RESULTS: The optimal extraction technique was to extract pueraria in 60% alcohol 8 times the weight of herbal medicine for 3 times, with 60 minute for each time. CONCLUSION: High yield of extractum and high content of pueraria are obtained with the present technology. The results are stable and replicable, which can provide reference for preparation of Huanglian powder.
Keywords:Huanglian powder  Orthogonal test  Puerarin  Extraction technology
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