| 非氨酯的合成 |
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| 引用本文： | 赵冬梅,刘瑶,吕久安,程卯生.非氨酯的合成[J].中国新药杂志,2005,14(12):1443-1444. |
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| 作者姓名： | 赵冬梅 刘瑶 吕久安 程卯生 |
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| 作者单位： | 1. 沈阳药科大学制药工程学院药化教研室,沈阳,110016
2. 东北制药总厂生产技术部,沈阳,110026 |
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| 摘 要： | 目的:合成非氨酯.方法:以2-苯基-1,3-丙二酸二乙酯为起始原料,经硼氢化钠还原后得到2-苯基-1,3-丙二醇,再与氯甲酸苯酯、氨水反应得到目标化合物非氨酯.结果:目标化合物经红外光谱、核磁共振氢谱、质谱确证其化学结构.非氨酯总收率达38.1%.结论:该法合成操作简便,适合于工业化生产.
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| 关 键 词： | 非氨酯 药物合成 抗癫痫药 |
| 文章编号： | 1003-3734（2005）12-1443-02 |
| 修稿时间： | 2005-06-16 |
Synthesis of felbamate |
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| ZHAO Dong-mei,LIU Yao,L Jiu-an,CHENG Mao-sheng.Synthesis of felbamate[J].Chinese Journal of New Drugs,2005,14(12):1443-1444. |
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| Authors: | ZHAO Dong-mei LIU Yao L Jiu-an CHENG Mao-sheng |
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| Affiliation: | 1 Department of Medicinal Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, China ; 2 Department of Production and Technology, Northeast General Pharmaceutical Factor, Shenyang 110026, China |
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| Abstract: | Objective:To synthesize felbamate.Methods:Starting from diethyl phenyl-malonate,felbamate was synthesized via several chemical reactions including reduction,acylation and hydrolysis.Results:The chemical structure of the target compound was confirmed by()~1H-NMR and MS analysis.The total yield of the target compound was 38.1%.Conclusion:An easily manipulated synthetic process of felbamate was attainable. |
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| Keywords: | felbamate synthesis antiepileptic drug |
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