2型糖尿病患者大血管病变与C反应蛋白的关系及辛伐他汀疗效分析

目的: 探讨2型糖尿病患者大血管病变与血浆C反应蛋白(CRP)的关系及辛伐他汀保护血管作用的机制。方法: 选择2型糖尿病(T2DM)患者69例,其中单纯T2DM组(A组)34例,T2DM并发大血管病变组(B组)35例,并选择20名健康体检者为对照组(C组)。采用免疫比浊法测定三组血清CRP水平,并观察辛伐他汀治疗A、B组前后CRP、血脂的变化。结果: A组和B组血清CRP水平均高于C组(P<0.05和P<0.01),B组也明显高于A组(P<0.01)。血清CRP与胆固醇(TC)、低密度脂蛋白(C-LDL)、氧化低密度脂蛋白(ox-LDL)、收缩压(SBP)、体重指数(BMI)均呈正相关关系(P<0.05~P<0.01),与高密度脂蛋白(C-HDL)呈负相关关系(P<0.01)。辛伐他汀治疗后血清CRP、TC、LDL和ox-LDL均明显下降(P<0.01)。结论: 血清CRP水平的检测对监测T2DM大血管病变的发生、发展有重要的临床意义。辛伐他汀通过抗炎、抗氧化及调脂作用而发挥其对T2DM大血管的保护作用。

Relationship between C-reative protein and type 2 diabetic macroangiopathy and analysis of the effect of simvastatin

Objective:To investigated the relationship between serum C-reactive protein (CRP)and macroangiopathy of type 2 diabetes millitus,and the mechanism of Simvastatin in protection of blood vessels.Methods:Sixty-nine cases of type 2 diabetes mellitus were selected,34 of whom had only type 2 diabetes with no complications(group A) and 35 of whom were accompanied by macroangiopathy(group B),and 20 healthy subjects acted as controls(group C).The serum CRP was determined by immuno-turbidimetric.The changes were observed before and after simvastatin treatment.Results:The serum CRP in group A and B were higher than that in group C(P<0.05 and P<0.01),while group B had higher serum CRP levels than group A(P<0.01).Serum CRP had a positive correlation with TC,C-LDL,ox-LDL,SBP,BMI(P<0.05 to P<0.01),and had a negative correlation with C-HDL(P< 0.01 ).After simvastatin treatment,the levels of serum CRP,TC,C-LDL,ox-LDL reduced remarkably(P<0.01).Conclusions:Serum CRP may play an important role in the development and progression of type 2 diabetic macroangiopathy.Simvastation protects the blood vessel by its mechanism of anti-inflammation,anti-oxidation and moderating lipid.