耐甲氧西林葡萄球菌医院感染耐药性分析

目的监测耐甲氧西林葡萄球菌（MRS）医院感染的临床分布和耐药现状，为临床医生正确选用抗菌药物提供参考依据。方法细菌培养与鉴定按《全国临床检验操作规程》进行，药敏试验采用纸片扩散法（K-B法），耐甲氧西林葡萄球菌的检测按美国临床实验室标准化委员会（NCCLS）进行。结果253株葡萄球菌属中，耐甲氧西林金黄色葡萄球菌（MRSA）检出率为29．9％；耐甲氧西林凝固酶阴性葡萄球菌（MRCNS）检出率为31.3％，远低于深圳、上海、武汉、北京和广州等发达城市；MRSA和MACNS对克林霉素、红霉素、环丙沙星等常用抗菌药物的耐药率均明显高于甲氧西林敏感葡萄球菌（MSS）。结论MRSA和MRCNS检出率不断升高，临床应重视耐药菌的检测与报告，及时有效地控制葡萄球菌属医院感染的发生与流行。

Antibiotic Resistance in Meticillin-resistant Staphylococcus

OBJECTIVE To investigate antibiotic resistance and distribution of meticillin-resistant Staphylococcus(MRS) and provide reference evidence in using antibiotics reasonably.METHODS Antibiotic susceptibility test was performed by K-B method and MRS were identified according to NCCLS(1999,2004).RESULTS Among 253 strains of Staphylococcus,meticillin-resistant S.aureus(MRSA) isolated ratio was 29.9% and meticillin-resistant coagulate-negative S.aureus(MRCNS)was 31.3%.The resistant ratio to clindamycin,erythromycin and ciprofloxacin in MRSA and MRCNS were higher than in meticillin-sensitive Staphylococcus(MSS) significantly.CONCLUSIONS The isolating ratio of MRSA and MRCNS is on rise.We should pay more attention to the identification and report of resistant strains and it is important to supervise nosocomial infection caused by Staphylococcus efficiently.