肠道菌群代谢转化中药皂苷类成分研究进展

近年来，肠道菌群代谢转化中药皂苷成为国内外研究的热点。中药皂苷类成分口服后难以直接在肠道中吸收，生物利用度低，肠道菌群产生的代谢酶可参与中药皂苷的代谢转化，使其生成低极性的次级苷、苷元或其他代谢物而发挥药理作用。通过综述中药皂苷在肠道菌群下的代谢反应、参与中药皂苷代谢转化的肠道菌群、代谢产物的活性、影响肠道菌群代谢转化中药皂苷的因素，为后续中药皂苷类成分在肠道中的代谢转化研究提供理论指导。

Research progress on metabolic transformation of traditional Chinese medicine saponins by intestinal flora

In recent years, the metabolic transformation of traditional Chinese medicine (TCM) saponins by intestinal flora has become a hot topic at home and abroad. The saponins of TCM are difficult to be absorbed directly in the intestine after oral administration, and their bioavailability is low. Metabolic enzymes produced by intestinal flora can participate in the metabolic transformation of saponins of TCM, making them produce low-polarity secondary glycosides, aglycones or other metabolites to play a pharmacological role. In this paper, the metabolic reaction of TCM saponins in intestinal flora, the intestinal flora involved in the metabolic transformation of TCM saponins, and the factors affecting the metabolic transformation of TCM saponins in intestinal flora were reviewed to provide theoretical guidance for the subsequent research on the metabolic transformation of TCM saponins in the intestine.