HLA antigens are associated in seronegativity to cytomegalovirus(CMV) |
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Authors: | S Machida T Takahashi K Nomoto S Murata |
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Affiliation: | Department of Medicine, University of Edinburgh, Royal Infirmary, UK. |
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Abstract: | The 5'-flanking region of human gamma-glutamylcysteine synthetase-heavy subunit (gamma-GCS-HS) was characterised by creating a series of chloramphenicol acetyl transferase (CAT) reporter deletion constructs. Analysis of various deleted CAT constructs revealed that a putative AP-1 consensus sequence is required to direct the constitutive and oxidant-mediated promoter activity. Gel mobility shift and mutation analysis of the sequence (-269 to -263 bp), showed binding of AP-1 is involved in the oxidant-mediated regulation of gamma-GCS-HS promoter activity. |
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