Solalyratins A and B,new anti-inflammatory metabolites from <Emphasis Type="Italic">Solanum lyratum</Emphasis> |
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| Authors: | De-Wu Zhang Yan Yang Fang Yao Qun-Ying Yu Sheng-Jun Dai |
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| Affiliation: | (1) School of Pharmaceutical Science, Yantai University, 264005 Yantai, People’s Republic of China;(2) Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, 100050 Beijing, People’s Republic of China; |
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| Abstract: | A new coumestan (solalyratin A, 1) and a novel cyclic eight-membered α,β-unsaturated ketone (solalyratin B, 3), together with three known compounds, puerariafuran (2), coumestrol (4) and 9-hydroxy-2′,2′-dimethylpyrano5′,6′:2,3]-coumestan (5), were isolated from the whole plant of Solanum lyratum. Their structures were elucidated on the basis of spectroscopic analyses. In vitro, compounds 1–5 showed anti-inflammatory activities, with IC50 values in the range 6.3–9.1 μM. |
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