Association between age and disease specific mortality in medullary thyroid cancer |
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| Authors: | Zeyad T Sahli Joseph K Canner Martha A Zeiger Aarti Mathur |
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| Affiliation: | 1. Department of Surgery, The University of Virginia Health System, P.O. Box 800681, Charlottesville, VA, 22908, USA;2. Endocrine Surgery, Department of Surgery, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Blalock 606, Baltimore, MD, 21287, USA;3. Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA;1. Department of Surgery, Mayo Clinic, 200th 1st Street, Rochester MN, 55905, USA;2. Department of Health Services Research, Mayo Clinic, 200th 1st Street, Rochester MN, 55905, USA;3. Mayo Clinic Robert D and Patricia E Kern Center for the Science of Health Care Delivery, 200th 1st Street, Rochester MN, 55905, USA;1. Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD;2. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD |
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| Abstract: | BackgroundThe aim of this study was to evaluate the association between age and disease specific mortality (DSM) among adults diagnosed with medullary thyroid cancer (MTC).MethodSurveillance, Epidemiology, and End Results (SEER-18) was used to analyze adult MTC patients stratified by age (18–64, 65–79, ≥80 years). Associations between patient demographics, tumor size, nodal status, metastatic disease, and extent of surgery on DSM was assessed with multivariable Cox regression.ResultsAmong 1457 patients with MTC, 1008 (69.2%) were younger adults, 371 (25.5%) older adults, and 78 (5.4%) were super-elderly. A significantly higher proportion of older adults and super-elderly had less than the recommended operation for MTC. On multivariable analysis, older adults and super-elderly were 2.9 and 6.7 times more likely to have an increased DSM (HR:2.91, 95% CI: 1.83–4.63; p < 0.001 and HR: 6.70, 95%CI: 3.69–12.20; p < 0.001). Extent of surgery or lymphadenectomy did not affect DSM.ConclusionsIncreased age is an independent predictor of DSM in patients with MTC. |
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| Keywords: | Medullary thyroid cancer Disease-specific mortality Aging Elderly Older adults Survival |
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