| 氯硝柳胺衍生物的透皮控释给药研究 |
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| 引用本文： | 杨云松,彭红云,章国林,戚国荣,杨士林.氯硝柳胺衍生物的透皮控释给药研究[J].应用化学,2001,18(12):944-0. |
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| 作者姓名： | 杨云松 彭红云 章国林 戚国荣 杨士林 |
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| 作者单位： | 浙江大学 |
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| 基金项目： | 国家自然科学基金资助项目(59673017) |
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| 摘 要： | 透皮给药;药物控释;氯硝柳胺衍生物的透皮控释给药研究
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| 关 键 词： | 透皮给药 药物控释 氯硝柳胺衍生物的透皮控释给药研究 |
| 文章编号： | 1000-0518(2001)12-0944-04 |
| 收稿时间： | 2009-06-29 |
| 修稿时间： | 2000年12月28 |
Transdermal Therapeutic Study of Niclosamide Derivatives |
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| YANG Yun-Song a,PENG Hong-Yun b,ZHANG Guo-Lin c,QI Guo-Rong a,YANG Shi-Lin a.Transdermal Therapeutic Study of Niclosamide Derivatives[J].Chinese Journal of Applied Chemistry,2001,18(12):944-0. |
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| Authors: | YANG Yun-Song a PENG Hong-Yun b ZHANG Guo-Lin c QI Guo-Rong a YANG Shi-Lin a |
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| Affiliation: | YANG Yun-Song a,PENG Hong-Yun b,ZHANG Guo-Lin c,QI Guo-Rong a*,YANG Shi-Lin a |
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| Abstract: | The low melting point derivatives and the hydrophilic derivatives of niclosamide were designed and prepared to enhance the transdemal rate of niclosamide. Lowering the melting point of niclosamide by esterification with fatty acid did not have much effect on increasing the transdermal flux of niclosamide. However, the trend was evident that the lower the melting point, the greater the transdermal flux. Drugs with suitable octanol/water partition coefficient had great transdermal rate. The transdermal therapeutic system of complexing niclosamide with ethanolamine showed a more promising future than that of niclosamide for schistosomiasis control. |
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| Keywords: | niclosamide transdermal therapeutic system controlled release |
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