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| 2，4-二甲氧基苯甲醛的经济合成新工艺 | |
| 引用本文： | 陈汉庚,金宁人,陈新志.2，4-二甲氧基苯甲醛的经济合成新工艺[J].精细与专用化学品,2007,15(9):21-23,31. |
| 作者姓名： | 陈汉庚 金宁人 陈新志 |
| 作者单位： | 1. 浙江大学材料与化工学院,浙江,杭州,310027;浙江工业大学化工与材料学院,浙江,杭州,310014 2. 浙江工业大学化工与材料学院,浙江,杭州,310014 3. 浙江大学材料与化工学院,浙江,杭州,310027 |
| 摘 要： | 以1,3-二甲氧基苯为原料,经Vilsmeier法使用DMF直接甲酰化来经济合成2,4-二甲氧基苯甲醛,获得IR、NMR定性合格的产品,经正交试验优化后无需提纯即可制得纯度98.64%、收率94.2%的目标产物,精制后纯度可达到99.6%。 |
| 关 键 词： | 2 4-二甲氧基苯甲醛 1 3-二甲氧基苯 Vilsmeier反应 DMF甲酰化 |
| 修稿时间： | 2007年4月2日 |
Novel Economical Route for Synthesis of 2, 4-Dimethoxybenzaledhyde |
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| CHEN Han-geng,JIN Ning-Fen,CHEN Xin-zhi.Novel Economical Route for Synthesis of 2, 4-Dimethoxybenzaledhyde[J].Fine and Specialty Chemicals,2007,15(9):21-23,31. | |
| Authors: | CHEN Han-geng JIN Ning-Fen CHEN Xin-zhi |
| Abstract: | 2,4-Dimethoxybenzaldehyde was prepared using 1,3-dimethoxybenzene as raw material through Vilsmeier formylation with DMF directly. The compound was characterized by IR and NMR as a qualified product. Under the optimal conditions the product obtained from the orthogonal experiments could be given in 94.2% yield with purity of 98.64%, after purification the purity of final compound could be reached 99.6%. |
| Keywords: | 2 4-dimethoxybenzaldehyde 2 4-dimethoxybenzene Vilsmeier reaction formylation with DMF |
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