载顺铂超顺磁γ-Fe2O3纳米粒子的制备与表征*☆

背景：将化疗药物联接在磁性纳米载体上，在外加磁场的引导下使所载药物定向集中于靶向治疗部位，在增强疗效同时还可降低毒性不良反应。 目的：制备海藻酸钠改性的磁性纳米粒子及其负载顺铂药物，分析产物的磁学性质。 方法：通过Fe2+在乙醇胺水溶液中一步合成磁性纳米粒子，用海藻酸钠作偶联剂使磁性纳米粒子与顺铂相连，制备磁性纳米粒子药物。 结果与结论：X射线衍射花样证明产物为γ-Fe2O3纯相，透射电子显微镜表明磁性纳米粒子直径平均约10 nm，载顺铂后药物包覆于纳米粒子周围，磁化曲线显示纳米粒子为超顺磁性，核磁共振得到纳米粒子的弛豫率为0.116 02 mmol/ms。表明所制备磁性纳米粒子及其载顺铂超顺磁性纳米粒子药物性质稳定，具有作为磁性纳米粒子药物的特性。 关键词：磁性纳米粒子药物；顺铂；超顺磁性；Fe2O3；生物材料与药物控释 doi:10.3969/j.issn.1673-8225.2012.12.011

Preparation and characterization of cisplatin-loaded super paramagnetic gamma-Fe2O3 nanoparticles

BACKGROUND: Induced by external magnetic field, the chemotherapy drug loaded on magnetic nanocarrier can be directly collected on target therapy area, which will enhance the curative effect and reduce the toxicity and adverse reaction. OBJECTIVE: To prepare sodium alginate-modified magnetic nanoparticles and cisplatin-loaded magnetic nanoparticle medicine, and to study the magnetic properties of the products. METHODS: One-step reaction by the hydrolysis of Fe2+ in the aqueous solution of ethanolamine was employed for the preparation of magnetic nanoparticles. Sodium alginate was used as coupling agent to prepare magnetic nanoparticle medicine making magnetic nanoparticles and cisplatin interconnected. RESULTS AND CONCLUSION: X-ray diffraction patterns proved that the product was pure γ-Fe2O3 phase. Transmission electron microscope images indicated that the average diameter of magnetic nanoparticles was about 10 nm, which were coated by cisplatin. Super paramagnetic behavior could be detected in the magnetization curve. A relaxation rate of 0.116 02 mmol/ms was obtained by nuclear magnetic resonance. The as-prepared magnetic nanoparticles and the cisplatin-loaded magnetic nanoparticle medicine showed a good stability, the physical properties of which revealed that it had the potential characteristics as magnetic nanoparticle targeted medicine.