福建省鼠间肾综合征出血热流行病学调查

目的掌握福建省鼠间肾综合征出血热(HFRS)流行情况和疫源地分布,为控制HFRS的流行提供参考。方法根据福建省啮齿动物地理区划以及肾综合征出血热病例分布状况,选择18个县、市作为调查地区,用笼夜法捕鼠采集血清标本,用双抗原夹心ELISA法检测血清中抗汉坦病毒(Hantan virus,HV)抗体,分析鼠间HFRS流行情况。结果各个地区HV宿主动物种类分布不均衡,但以褐家鼠为主要宿主动物,其次为黄胸鼠,野外鼠密度较低。褐家鼠抗体阳性率最高,达到9.89%。各个地理区划中II区即闽东山地抗体阳性率最高,为9.32%,而III区即闽中、闽西南山地抗体阳性率最低,为2.74%。调查点中泰宁、周宁、福鼎、厦门、福清、莆田、平潭等地鼠血清HV抗体阳性率均超过10%。而上杭、漳平、漳浦、安溪等地鼠血清均未检出HV抗体。结论福建省HFRS的疫源地以家鼠型疫区为主,降低家鼠尤其是褐家鼠密度,可控制本病在福建的扩大流行。

Sero-epidemic investigation of hemorrhagic fever with renal syndrome in rodents of Fujian province

To understand the prevalence and epidemic foci of hemorrhagic fever with renal syndrome(HFRS) in rodents of Fujian province,Eighteen counties from 4 geographic zones,which were previously divided according to climatic and geographic characters in the province,were selected for the investigation.Serum specimens were collected from rodents captured by the overnight-cage capturing method.By means of the double antigens sandwich ELISA,the results of antibody detection showed that although species distribution in the infected rodents was disproported in these investigated areas,Rattus norveqicus as the highest prevalence rate to 9.89% for HV antibodies,was the principal hosts of infective agents of HFRS,next was R.flavipectus.Rodent densities seemed no high in fields.In concerning of the geographic zones,the highest prevalence rate was 9.32% in zone II,and the lowest was 2.74%in zone III.The prevalence rate in 7 counties,such as Taining,Zhouning,Fuding,Xiameng,Fuqing,Putian,Pingtang,all surpassed 10%.However the low rates were observed in Shanghang,Zhangping,Zhangpu and Anxi counties.These results suggested that Seoul virus is a predominant serotype in Fujian province.The HFRS epidemic could be controlled by depressing the densities of house rates,especially for R.flavipectus.