埃索美拉唑三联与奥美拉唑三联疗法治疗Hp阳性十二指肠溃疡对比研究

目的 比较埃索美拉唑三联与奥美拉唑三联疗法治疗幽门螺杆菌(Hp)阳性十二指肠球部溃疡的临床疗效。方法 将104例经内镜诊断并检测证实Hp阳性的十二指肠球部溃疡患者随机分为两组。埃索美拉唑组(52例):埃索美拉唑20mg+阿莫西林1g+克拉霉素500mg,每日2次,共7d;奥美拉唑组(52例):奥美拉唑20mg+阿莫西林1g+克拉霉素500mg,每日2次,共7d。疗程结束4周后复查胃镜并检测Hp,观察腹痛缓解率、溃疡愈合率、Hp根除率及用药后的不良反应等。结果 埃索美拉唑组第1天和第2天腹痛缓解率分别为34.6%和59.6%,高于奥美拉唑组的17.3%和38.5%(P<0.05)。埃索美拉唑组和奥美拉唑组溃疡愈合率分别为92.3%和88.5%,Hp根除率分别为88.5%和82.7%,差异无显著性(P>0.05)。两组用药后不良反应少,有较好的安全性。结论 埃索美拉唑三联疗法治疗Hp阳性的十二指肠溃疡安全有效,腹痛缓解速度优于奥美拉唑三联疗法。

Comparison of esomeprazole-and omeprazole-based triple therapy regimens for duodenal ulcer with Helicobacter pylori infection

Objective To investigate the effect of esomeprazole- and omeprazole-based triple therapy regimens in the treatment of duodenal ulcer with Helicobacter pylori (Hp) infection. Methods Totally 104 patients with duodenal ulcer and Hp infection were randomly divided into group A (52 cases) treated with esomeprazole (20 mg), amoxicillin (1 000 mg) and clarithromycin (500 mg) twice daily and group B (52 cases) treated with omeprazole (20 mg), amoxicillin (1000 mg) and clarithromycin (500 mg) twice daily. The treatment lasted for 7 days, after which abdominal pain relief rate, ulcer healing rate and eradication rate of Hp as well as adverse effects of the medication were evaluated and compared. Results On the first and second days of medication, the abdominal pain relief rates were 34.6% and 59.6 % respectively in group A, significantly higher than those in group B (17.3% and 38.5%, respectively, P<0.05). Ulcer healing rate and Hp eradication rate were 92.3% and 88.5 % in group A, and 88.5% and 82.7% in group B, showing no significant differences between the two groups (P>0.05). The adverse effects of the medication were rare in both groups without significant differences. Conclusion Esomeprazole-based triple therapy may effectively eradicate Hp infection and promote duodenal ulcer healing with good tolerance, capable of achieving more speedy pain relief than omeprazole-based therapy.