Noninvasive assessment and risk factors of liver fibrosis in patients with thalassemia major using shear wave elastography |
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| Authors: | Murtadha Al-Khabori Shahina Daar Said A Al-Busafi Humoud Al-Dhuhli AlGhalya A Alumairi Moez Hassan |
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| Affiliation: | 1. Department of Haemtology, Sultan Qaboos University Hospital, Sultan Qaboos University, Muscat, Omankhabori@squ.edu.omkabori@yahoo.com https://orcid.org/0000-0002-2937-8838;4. Department of Haemtology, College of Medicine &5. Health Sciences Sultan Qaboos University, Muscat, Oman;6. Stellenbosch Institute for Advanced Study (STIAS), Wallenberg Research Centre at Stellenbosch University, Stellenbosch, South Africa;7. Gastroenterology and Hepatology Unit Department of Medicine, Sultan Qaboos University Hospital Sultan Qaboos University, Muscat, Oman;8. Department of Radiology and Molecular Imaging, Sultan Qaboos University Hospital Sultan Qaboos University, Muscat, Oman;9. Internal Medicine Program, Oman Medical Specialty Board, Muscat, Oman;10. Department of Haemtology, Sultan Qaboos University Hospital, Sultan Qaboos University, Muscat, Oman |
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| Abstract: | Objectives: This study aimed to estimate the prevalence of liver fibrosis and assess the risk factors for developing significant liver fibrosis in patients with Thalassemia Major (TM).Methods: All patients with TM over the age of 10 years were included in the study.Results: A total of 94 eligible patients underwent 2-D SWE. The median age was 26.7 years. The median of the average 5-year serum ferritin (5yrSF) and liver iron concentration (LIC) assessed by MRI T2* were 1326?µg/L and 6.7?mg/g?dw, respectively. Hepatitis C and hepatitis B core antibodies were positive in 38% and 1% of the patients respectively. The proportion of patients with significant fibrosis was 60%. Male gender increased the risk of significant fibrosis (Odds ratio of 0.4; p?=?.0373). Additionally, the 5yrSF (p?=?.00661), the LIC (p?=?.0225) and the lowest LIC of the previous 5 years (p?=?.0211) were significant. In the multivariable logistic regression model, only 5yrSF (p?=?.0035) and gender (p?=?.00984) remained significant.Conclusions: The risk of liver fibrosis is associated with iron overload and gender in patients with TM. |
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| Keywords: | Beta thalassemia major iron overload ultrasound liver fibrosis risk factors |
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![ORCID Icon]({"type":"image","src":"/templates/jsp/images/orcid.png"} "ORCID Icon")
https://orcid.org/0000-0002-2937-8838;4. Department of Haemtology, College of Medicine &5. Health Sciences Sultan Qaboos University, Muscat, Oman;6. Stellenbosch Institute for Advanced Study (STIAS), Wallenberg Research Centre at Stellenbosch University, Stellenbosch, South Africa;7. Gastroenterology and Hepatology Unit Department of Medicine, Sultan Qaboos University Hospital Sultan Qaboos University, Muscat, Oman;8. Department of Radiology and Molecular Imaging, Sultan Qaboos University Hospital Sultan Qaboos University, Muscat, Oman;9. Internal Medicine Program, Oman Medical Specialty Board, Muscat, Oman;10. Department of Haemtology, Sultan Qaboos University Hospital, Sultan Qaboos University, Muscat, Oman