大剂量氨溴索联合乌司他丁治疗急性呼吸窘迫综合征的临床观察

目的 观察氨溴索联合乌司他丁治疗急性呼吸窘迫综合征（ARDS）的临床效果.方法 ARDS患者67例,按随机数字表分为治疗组36例和对照组31例,两组均给予常规治疗方法,治疗组加大剂量氨溴索联合乌司他丁治疗,对照组加甲强龙静脉注射.治疗10 d后,观察两组的临床疗效,以及治疗前后APACHEⅡ评分、肺损伤评分、机械通气率、住院时间、PaO2、SaO2、PaO2/ FiO2.方法 治疗10 d后治疗组总有效率为83.3%,高于对照组的61.3%,差异有统计学意义（P＜0.05）;APACHEⅡ评分、肺损伤评分、PaO2、SaO2和PaO2/ FiO2改善均优于对照组（P＜0.05）,住院时间短于对照组（P＜0.05）.结论 大剂量氨溴索联合乌司他丁治疗ARDS疗效好,可缩短住院时间,对提高诊疗质量具有积极的意义.

Clinical Observation of Combination of Large Doses of Ambroxol and Ulinastatin in Treating Acute Respiratory Distress Syndrome

Objective To observe the clinical effects of the acute respiratory distress syndrome（ARDS）for large doses of ambroxol combining with ulinastatin. Methods Sixty-seven patients with ARDS were randomly divided into treatment group（36 cases）and control group（S1 cases）. The two groups were treated by the conventional treatment ,and the treatment group added large doses of ambroxol combined with ulinastatin,and the control group added methylprednisolone. The clinical efficacy,APACHEⅡ and lung injury score before and after treatment, incidence of mechanical ventilation, hospital stay and the PaO2, SaO2, PaO2/SaO2 before and after treatment of the two groups ten days after treatment were observed. Results The total effective rate was 83.3% and 61.3% in treatment group and control group respectively 10 days after treatment, the differences was significant （ P 〈 0.05 ）. The APACHE Ⅱ and lung injury score, incidence of mechanical ventilation, hospital stay and PaO2, SaO2, PaOE/SaO2 of the treatment group were better than the control groups ten days after treatment （P 〈 0.05）. Conclusion It is good for the patients of ARDS treated with combination of large doses of ambroxol and ulinastatin. It can short the hospital stay and is of positive significance to improve the quality of diagnosis and treatment.