倍频Nd:YAG激光治疗早产儿视网膜病变疗效分析

Objective To analyze the treatment efficacy of frequency-doubled Nd-YAG laser indirect photocoagulation for retinopathy of prematurity (ROP). Methods The clinical records in 39 preterm infants (76 eyes) treated by 532nm frequency-doubled Nd-YAG laser were retrospectively analyzed. Various risk factors were compared between the patients with zone Ⅰ ROP and zone Ⅱ ROP. Results Seventy-six eyes with ROP were cured via the laser photocoagulafion with the curative rate 93.42%. The mean birth weight, gestational age in 16 infants of zone Ⅰ ROP was 1232±325g, 28.79±1.93 weeks, and the data above mentioned had no significant difference in comparison with the 23 infants with zone Ⅱ disease group (1333±264g,29.47±2.11 weeks) (P >0.05 ). The corrected gestational at the time of operation with zone Ⅰ disease (34.29±1.44weeks ) was less than that zone Ⅱ disease group ( 36.00±2.03weeks ) (P <0.05 ). The laser spots of zone Ⅰ ROP (1618±607 ) were much more than that of zone Ⅱ ROP (813±470 )(P<0.05).Conclusions Patients with zone Ⅰ ROP always progress quickly and show a poor outcome. Frequency-doubled Nd-YAG laser retinal photocoagulation is a safe and effective procedure for treatment of zone Ⅰ and Ⅱ of ROP.

Treatment outcome of retinopathy of prematurity by frequency-doubled Nd-YAG laser indirect photocoagulation