| 硒锌水平对染铅大鼠股骨中微量元素及矿物质含量的影响 |
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| 引用本文： | 赖建强,周静,荫士安.硒锌水平对染铅大鼠股骨中微量元素及矿物质含量的影响[J].卫生研究,2004,33(5):584-586. |
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| 作者姓名： | 赖建强 周静 荫士安 |
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| 作者单位： | 中国疾病预防控制中心营养与食品安全所,北京,100050 |
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| 基金项目： | 国家“九五”科技攻关课题的分题 (No .96 90 4 0 6 0 6) |
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| 摘 要： | 目的 以大鼠为模型 ,观察饲料中添加不同亚硒酸钠 (Se 0 1、0 5和 1 0mg kg)、乳酸锌 (Zn 10、5 0和 2 0 0mg kg)对醋酸铅 (Pb 0、2 0 0mg kg)所致骨骼毒性的拮抗作用。方法 断乳一周Wistar雄性大鼠按体重随机被分成 10组 ,每组 10只。其中 10组添加了不同铁、锌和铅水平的饲料 ,12周后处死大鼠测定股骨生长发育有关指标 ,结果 染铅抑制大鼠骨骼的生长发育 ,降低骨骼中矿物质含量和骨密度 ,补充硒锌后能改善大鼠股骨的重量和长度 ,增加股骨矿物质含量和骨密度 ,同时降低骨铅含量。结论 需要进一步研究铅影响骨骼生长发育的机制
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| 关 键 词： | 硒 锌 铅 骨密度 |
| 文章编号： | 1000-8020(2004)05-0584-03 |
| 修稿时间： | 2004年7月8日 |
Effect of selenium and zinc level in diet on bone development in rats exposed to lead |
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| Lai Jianqiang,Zhou Jing,Yin Shian Institute of Nutrition and Food Safety,Chinese Center for Disease Control and Prevention,Beijing ,China.Effect of selenium and zinc level in diet on bone development in rats exposed to lead[J].Journal of Hygiene Research,2004,33(5):584-586. |
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| Authors: | Lai Jianqiang Zhou Jing Yin Shian Institute of Nutrition and Food Safety Chinese Center for Disease Control and Prevention Beijing China |
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| Affiliation: | Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China. |
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| Abstract: | Objective To explore the interaction role of selenium and zinc in diet on bone development in rats exposed to lead, and to observe the change of bone mineral content (BMC) and bone mineral density(BMD). Methods Weans male Wistar rats were fed with diet added with different levels of selenium, zinc and lead for 12 weeks. Results long-term exposure to lead may inhibit the development of bone and reduce BMC and BMD, however, selenium and zinc in the diets could improve the inhibit effect of lead on weight and length, BMC and BMD of rat bone. Conclusion The present study indicated that supplementing suitable amount of selenium or/and zinc could interact the side effect of lead, and increase the BMC and BMD of rat bone. The interaction mechanism of iron and zinc on bone exposed to lead in diets needs to be explore in further. |
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| Keywords: | selenium zinc lead bone mineral content bone mineral density |
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