原发性肝癌中医常见基本证候轻重程度量化评价研究

目的 构建原发性肝癌中医常见基本证候轻重程度量化评价模型。方法 收集国内有关原发性肝癌症状与证候相关研究文献，以“综合集成研讨厅”专家研讨的方法，应用100mm刻度法结合症状轻重分级赋分法建立症状体征量化规范。以综合评价层次分析法作为证候量化评价的数学工具，组织专家对基本证候的各层次评价指标进行权重估计，构建两种基本证候轻重程度量化评价层次分析模型，即相加模型与相加相乘模型，通过临床验证，将这两种模型的量化计算结果与专家模糊判断结果进行比较。结果 在对459例次原发性肝癌患者的临床验证结果表明，相加模型运算结果与专家模糊判断符合率为84．53％，相加相乘模型符合率为62．75％，两者比较差异有显著性（P〈0．01）。结论 确定相加模型为原发性肝癌基本证候轻重程度量化评价的基本模型。

Study on the Quantitative Evaluation on the Degree of TCM Basic Syndromes Often Encountered in Patients with Primary Liver Cancer

Objective To establish a quantitative model for evaluating the degree of the TCM basic syndromes often encountered in patients with primary liver cancer(PLC).Methods Medical literatures concerning the clinical investigation and TCM syndrome of PLC were collected and analyzed adopting expert-composed symposium method,and the 100 millimeter scaling was applied in combining with scoring on degree of symptoms to establish a quantitative criterion for symptoms and signs degree classification in patients with PLC.Two models,i.e.the additive model and the additive-multiplicative model,were established by using comprehensive analytic hierarchy process(AHP)as the mathematical tool to estimate the weight of the criterion for evaluating basic syndromes in various layers by specialists.Then the two models were verified in clinical practice and the outcomes were compared with that fuzzy evaluated by specialists.Results Verification on 459 times/case of PLC showed that the coincidence rate between the outcomes derived from specialists with that from the additive model was 84.53%,and with that from the additive-multificative model was 62.75%,the difference between the two showed statistical significance(P<0.01).Conclusion It could be decided that the additive model is the principle model suitable for quantitative evaluation on the degree of TCM basic syndromes in patients with PLC.