| 线粒体自噬与心力衰竭 |
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| 引用本文： | 周爽,蒋智渊,钟国强.线粒体自噬与心力衰竭[J].中国病理生理杂志,2020(5):924-929,935. |
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| 作者姓名： | 周爽 蒋智渊 钟国强 |
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| 作者单位： | 广西医科大学第一附属医院心血管内科 |
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| 基金项目： | 国家自然科学基金资助项目(No.81660054);广西自然科学基金资助项目(No.2016GXNSFBA380115,No.2017GCNSFAA198053)。 |
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| 摘 要： | 心力衰竭(简称心衰)是指由于心脏功能障碍导致心室充盈或射血能力受损的一种复杂的综合征。目前,我国35岁以上人群慢性心衰的患病率约为0.9%1]。随着人口老龄化,冠心病、高血压、糖尿病等慢性病的发病率增加,以及对急性心血管疾病治疗手段的提高,心衰的患病率必然进一步增加。
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| 关 键 词： | 线粒体 自噬 心力衰竭 |
Mitophagy and heart failure |
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| ZHOU Shuang,JIANG Zhi-yuan,ZHONG Guo-qiang.Mitophagy and heart failure[J].Chinese Journal of Pathophysiology,2020(5):924-929,935. |
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| Authors: | ZHOU Shuang JIANG Zhi-yuan ZHONG Guo-qiang |
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| Affiliation: | (Department of Cardiovascular Medicine,First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China) |
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| Abstract: | Heart failure(HF)is the end stage of various cardiovascular diseases. The prognosis of patients with HF is poor. The precise pathophysiological mechanism of HF is still not fully elucidated. Recent studies have shown that mitochondrial dysfunction is closely associated with HF. Mitophagy plays a crucial role in mitochondrial quality control. In this article,we review the present evidence implicating the role of mitophagy in HF,and provide the potential therapeutic strategies targeting mitophagy to improve outcome in the patients with HF. |
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| Keywords: | Mitochondrion Autophagy Heart failure |
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