| 3.0TMR质子波谱成像诊断难治性颞叶癫痫海马硬化的价值 |
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| 引用本文： | 曾文兵,秦媛,汪明全,杨染,高才良,温云.3.0TMR质子波谱成像诊断难治性颞叶癫痫海马硬化的价值[J].河南诊断与治疗杂志,2014(8):806-807. |
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| 作者姓名： | 曾文兵 秦媛 汪明全 杨染 高才良 温云 |
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| 作者单位： | 重庆三峡中心医院放射科,重庆404100 |
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| 基金项目： | 重庆市卫生局医学科研计划项目（2010-2-364） |
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| 摘 要： | 目的探讨3.0T MR质子波谱成像（proton magnetic resonance spectroscopy,1 H-MRS）在难治性颞叶癫痫海马硬化早期诊断中的应用价值。方法 64例难治性颞叶癫痫海马硬化患者（观察组）,行1 H-MRS检查,分析海马N-乙酰基天门冬氨酸（N-acetylaspartate,NAA）、胆碱复合物（choline,Cho）与肌酸复合物（creatine-phosphocreatine,Cr）波峰特点及NAA/（Cho＋Cr）比值,与21例体检健康者（对照组）进行比较。结果观察组1 H-MRS检查发现左侧海马异常10例,右侧异常7例,双侧异常47例;与对照组比较,观察组海马异常侧1 H-MRS图像主要表现为NAA波峰降低,Cr和Cho波峰增高;观察组海马单侧异常者患侧NAA/（Cho＋Cr）值（0.484±0.145）低于健侧（0.846±0.120）（P〈0.05）,双侧异常者主要异常侧NAA/（Cho＋Cr）值（0.382±0.115）低于对侧（0.563±0.167）（P〈0.05）;对照组双侧NAA/（Cho＋Cr）均值为0.843±0.122,高于观察组海马单侧异常者患侧、双侧异常者双侧（P〈0.05）。结论 1 H-MRS可反映神经元的丢失和/或胶质细胞增生,在难治性颞叶癫痫海马硬化早期诊断中有重要价值。
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| 关 键 词： | 颞叶癫痫 海马硬化 磁共振质子波谱成像 |
Value of 3.0T MR spectroscopy imaging to the diagnosis of refractory hippocampal sclerosis in patients with temporal lobe epilepsy |
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| ZENG Wen-bing,QIN Yuan,WANG Ming-quan,YANG Ran,GAO Cai-liang,WEN Yun.Value of 3.0T MR spectroscopy imaging to the diagnosis of refractory hippocampal sclerosis in patients with temporal lobe epilepsy[J].Henan Journal of Diagnosis and Therapy,2014(8):806-807. |
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| Authors: | ZENG Wen-bing QIN Yuan WANG Ming-quan YANG Ran GAO Cai-liang WEN Yun |
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| Affiliation: | (Department of Radiology, Central Hospital of Chongqing Three Gorge, Chongqing 404100, China) |
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| Abstract: | Objective To explore the value of proton magnetic resonance spectroscopy（1 H-MRS）to the early diagnosis of refractory sclerotic hippocampus in patients with temporal lobe epilepsy（TLE）.Methods Sixty-four TLE patients with hippocampal sclerosis（observation group）received 1 H-MRS to analyze the features of N-acetylaspartate（NAA）,choline（Cho）and creatine-phosphocreatine（Cr）and to calculate NAA/（Cho＋Cr）ratio,and were compared with 21 healthy volunteers（control group）.Results In observation group,1 H-MRS showed left lateral hippocampus abnormality in 10 patients,right lateral hippocampus abnormality in 7,and bilateral abnormality in 47.1 H-MRS showed lower NAA wave peak and higher Cr and Cho wave peak in observation group.NAA/（Cho＋Cr）ratio was 0.484±0.145 in abnormal hippocampus,significantly lower than that in normal hippocampus（0.846±0.120）（P〈0.05）,and was 0.382±0.115 in abnormal hippocampus,significantly lower than that in normal hippocampus（0.563±0.167）in observation group（P〈0.05）.The NAA/（Cho＋Cr）was 0.843±0.122 in both sides of hippocampus in control group,higher than that in patients with hippocampus abnormality（P〈0.05）.Conclusion 1 H-MRS can reflect the loss of neurons and/or gliocyte proliferation,which plays an important role in the early treatment of clinical temporal lobe epilepsy. |
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| Keywords: | Temporal lobe epilepsy hippocampal sclerosis proton magnetic resonance spectroscopy |
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