| 传染性单核细胞增多症外周血B淋巴细胞CD21的表达 |
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| 引用本文： | 张融,王琼瑾,徐金梅,蒋犁,寿伟璋.传染性单核细胞增多症外周血B淋巴细胞CD21的表达[J].实用儿科临床杂志,2005,20(3):249-250. |
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| 作者姓名： | 张融 王琼瑾 徐金梅 蒋犁 寿伟璋 |
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| 作者单位： | 1. 东南大学医学院附属扬州医院
2. 东南大学临床医学院,江苏,扬州,225001 |
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| 基金项目： | 扬州市卫生局科技招标立项课题 [扬卫教 (2 0 0 3) 1 9号 ] |
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| 摘 要： | 目的 探讨外周血B淋巴细胞CD2 1 的表达在传染性单核细胞增多症 (IM)发病机制中的作用。方法 用流式细胞术测定IM患儿 38例、新生儿 1 4例、对照组 1 4例的外周血B淋巴细胞CD2 1 表达水平。结果 IM组外周血中B淋巴细胞比例、表达CD2 1 B淋巴细胞数及B淋巴细胞表达CD2 1 位点均高于 2个对照组 (P <0 .0 5 ,P <0 .0 1 )。结论 EB病毒 (EBV)感染可诱导B淋巴细胞持续高表达CD2 1 ,以利于病毒进入细胞并导致潜伏型感染和增殖性感染。
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| 关 键 词： | 单核细胞增多症 传染性 EB 病毒 B淋巴细胞 CD21 |
| 文章编号： | 1003-515X(2005)03-0249-02 |
| 修稿时间： | 2005年1月7日 |
Expression of CD21 on Peripheral Blood B Lymphocytes in Children with Infectious Mononucleosis |
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| ZHANG Rong,WANG Qiong-jin,XU Jin-mei,JIANG Li,SHOU Wei-zhang.Expression of CD21 on Peripheral Blood B Lymphocytes in Children with Infectious Mononucleosis[J].Journal of Applied Clinical Pediatrics,2005,20(3):249-250. |
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| Authors: | ZHANG Rong WANG Qiong-jin XU Jin-mei JIANG Li SHOU Wei-zhang |
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| Affiliation: | ZHANG Rong1,WANG Qiong-jin1,XU Jin-mei1,JIANG Li2,SHOU Wei-zhang2 |
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| Abstract: | Objective To investigate the expression of CD_ 21 on peripheral blood B lymphocytes in children with infectious mononucleosis(IM).Methods The expression of CD_ 21 on B lymphocytes were analyzed with flow cytometry in IM group and two control groups.Results The ratio of B lymphocytes,the number of B lymphocytes expressing CD_ 21,and the number of CD_ 21 on B lymphocyte were significantly higher in IM group than two control groups(P<0.05,P<0.01).Conclusion Infection of Epstein-Barr virus (EBV) could induce B lymphocytes expression CD_ 21 with higher level, and benefit to EBV enter cells and lead to latent and proliferative infection. |
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| Keywords: | infectious mononucleosis Epstein-Barr virus B lymphocyte CD_ 21 |
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