| 三组分一锅法合成1-羧甲基-6-芳基-1,2,3,4,5,6-六氢茚并[2,3-b]-喹啉-5,11-二酮 |
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| 引用本文： | 陈艳,屠树江,姜波,李春梅.三组分一锅法合成1-羧甲基-6-芳基-1,2,3,4,5,6-六氢茚并[2,3-b]-喹啉-5,11-二酮[J].有机化学,2007,27(10):1288-1291. |
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| 作者姓名： | 陈艳 屠树江 姜波 李春梅 |
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| 作者单位： | 1. 徐州工程学院化学化工学院,徐州,221008
2. 徐州师范大学化学化工学院,江苏省药用植物生物技术重点实验室,徐州,221116 |
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| 基金项目： | 国家自然科学基金(No.20672090)，江苏省自然科学基金(No.BK2006033)，江苏省青蓝工程基金(No.QL200512)，徐州教育学院院长基金(No.2006HX03)资助项目 |
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| 摘 要： | 以芳醛、1,3-茚二酮、烯胺酮为原料, 冰醋酸为溶剂, 三组分一锅法合成了一系列茚并2,3-b]喹啉类化合物. 该反应产率高(83%～93%)、操作简单、后处理方便. 产物的结构通过红外光谱、核磁共振谱和元素分析证实, 同时给出了该反应可能的反应机理.
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| 关 键 词： | 1-羧甲基-6-芳基-1 2 3 4 5 6-六氢茚并[2 3-b]喹啉-5 11-二酮 芳醛 1 3-茚二酮 烯胺酮 合成 |
| 收稿时间： | 2006-11-21 |
| 修稿时间： | 2006-11-21 |
Three-Component One-Pot Synthesis of 1-Carboxymethy-6-aryl-1,2,3,4,5,6-hexahydroindeno[2,3-b]quinoline-5,11-dione |
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| CHEN Yan,TU Shu-Jiang,JIANG Bo,LI Chun-Mei.Three-Component One-Pot Synthesis of 1-Carboxymethy-6-aryl-1,2,3,4,5,6-hexahydroindeno[2,3-b]quinoline-5,11-dione[J].Chinese Journal of Organic Chemistry,2007,27(10):1288-1291. |
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| Authors: | CHEN Yan TU Shu-Jiang JIANG Bo LI Chun-Mei |
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| Affiliation: | 1 School of Chemistry and Chemical Engineering, Xuzhou Institute of Technology College, Xuzhou 221008;b Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116 |
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| Abstract: | A series of indeno2,3-b]quinoline-5,11-diones were synthesized by the one-pot three component reaction of aromatic aldehydes, 1,3-indanedione and enaminones in acetic acid. This method has the advan-tage of high yields (83%～93%) and simple workup procedure. The structures of the products were identi-fied by IR, 1H NMR spectra and elemental analysis. In addition mechanism to account for the reaction was proposed. |
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| Keywords: | 1-carboxymethy-6-aryl-1 2 3 4 5 6-hexahydroindeno[2 3-b]quinoline-5 11-dione aromatic aldehyde 1 3-indanedione enaminone synthesis |
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