血清EBV抗体检测联合99mTC-MIBI显像和MRI在诊断鼻咽癌放射治疗后复发中的价值

目的:探讨血清EBV抗体检测联合^99mTc-MIBI显像和MRI在诊断鼻咽癌放射治疗后复发中的价值。方法:60例鼻咽癌放射治疗后患者依据病理组织活检和临床随访复发21例,随访中均行血清EBV抗体检测、^99mTc-MIBI显像显像和MRI检查。分别评价三者对鼻咽癌放疗后复发检出的灵敏度、特异性和准确度进行比较。结果:联合3种检查方法诊断鼻咽癌放疗后复发的灵敏度、特异性和准确率分别为100%、97.44%、和98.33%,其中灵敏度与单一检查方法比较差异无统计学意义;特异性与亲肿瘤显像比较差异无统计学意义,但与血清EBV抗体检测和MRI检查差异均具有统计学意义;准确率与单一检查方法差异均有统计学意义。结论:联合血清EBV抗体检测、^99mTc-MIBI显像和MRI在诊断鼻咽癌放射治疗后复发中具有较高的价值,三种诊断方法有各自的优缺点,三者结合起来应用,可明显提高诊断鼻咽癌放射治疗后复发的准确性。

The detection of serum EBV antibody,99mTc-MIBI imaging and MRI in the diagnosis of nasopharyngeal carcinoma recurrence after radiotherapy

Objective:To evaluate the value of serum EBV antibody,^99mTc-MIBI imaging and MRI in the diagnosis of nasopharyngeal carcinoma（NPC） recurrence after radiotherapy.Methods:Sixty patients who had NPC after radiotherapy were confirmed by pathology including 21 cases of local recurrence.Serum EBV antibody,^99mTc-MIBI scintigraphy and MRI imaging in all patients were detected in which diagnostic efficacy was analysed.Results:The sensitivity,specificity and accuracy of united three methods were respectively 100%,97.44% and 98.33%.The sensitivity was no singnificant difference between united three methods and a single method.The specificity was no singnificant difference between united three methods and^99mTc-MIBI scintigraphy,while had singnificant difference with EBV antibody test and MRI.The accuracy had singnificant difference between united three methods and a single method.Conclusion:United serum EBV antibody test,^99mTc-MIBI imaging and MRI in the diagnosis of recurrence after radiotherapy have a higher value,and a single method have its advantage and disadvantage,so united three methods can improve the diagnosis of nasopharyngeal carcinoma recurrence after radiotherapy.