| 回生丸的脱毒药效学评价 |
| |
| 引用本文： | 何蕾,崔艳英,陈素青,朱蓉,宁亚清,潘励山.回生丸的脱毒药效学评价[J].中国药物依赖性杂志,2005,14(3):190-193. |
| |
| 作者姓名： | 何蕾 崔艳英 陈素青 朱蓉 宁亚清 潘励山 |
| |
| 作者单位： | 北京大学中国药物依赖性研究所,北京,100083 |
| |
| 摘 要： | 目的:评价回生丸的脱毒药效学。方法:采用剂量递增法建立吗啡依赖大鼠催促戒断模型、吗啡依赖大鼠自然戒断模型以及吗啡依赖猴自然戒断模型,然后给予回生丸进行治疗。结果:回生丸2·88、5·76g·kg-1两个剂量可显著降低吗啡依赖大鼠催促戒断症状的分值(P<0·05),但对体重下降的抑制不明显(P>0·05);回生丸和可乐定均不能控制吗啡依赖大鼠自然戒断的体重下降(P>0·05);回生丸3·2、6·4g·kg-1两个剂量均能在不同程度上控制吗啡依赖猴自然戒断的戒断症状,抑制体重下降(P<0·05或P<0·01)。结论:回生丸对吗啡依赖动物的戒断反应表现出明显的抑制作用。
|
| 关 键 词： | 键词回生丸 吗啡依赖性 脱毒药效学 |
| 收稿时间： | 2004-10-25 |
| 修稿时间： | 2004年10月25 |
EVALUATION ON DETOXIFICATION EFFECT OF HUISHENG PILL |
| |
| HE Lei,CUI Yanying,CHEN Suqing,ZHU Rong,NING Yaqing,PAN Lishan.EVALUATION ON DETOXIFICATION EFFECT OF HUISHENG PILL[J].Chinese Journal of Drug Dependence,2005,14(3):190-193. |
| |
| Authors: | HE Lei CUI Yanying CHEN Suqing ZHU Rong NING Yaqing PAN Lishan |
| |
| Abstract: | Objective: To evaluate the detoxification effect of Huisheng pill. Methods: Models of morphine-dependent rats and monkeys were established by dose-increasing administration. After precipitated by naloxone or natural withdrawal,the abstinent syndromes and weight loss of addictive rats and monkeys were observed. Results: Huisheng pills 2.88 and 5.76 g·kg~ -1 significantly decreased the score of withdrawal syndromes (P<0.05) but did not control the weight loss (P>0.05) on the rat models of withdrawal test. Neither Huisheng pills nor clonidine controlled the weight loss(P>0.05) on the rat models of withdrawal test. Huisheng pills 3.2 and 6.4 g·kg~ -1 controlled the withdrawal syndromes and inhibited the weight loss of monkeys (P<0.05 or P<0.01).Conclusion: Huisheng pills show a significant detoxification effect on models of morphine-dependent rats and monkeys. |
| |
| Keywords: | Huisheng pill morphine-dependence detoxification effect |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
