Abstract: | A large number of animal experiments and clinical trials have shown the potential positive effects of hydrogen on the prevention or treatment of diseases. Although the safety of hydrogen has been widely recognized at present, there are still a lack of experimental data supporting whether long-term hydrogen intervention affects the physiological function of the body. In order to explore the effects of long-term drinking of hydrogen-rich water (HRW) on the physiological function, we elaborated the body and organ weight of rats, the changes of water, food intake, feces and urine excretions, and the cardiac function. Besides, the blood indicators were also monitored. The results were as follows: HRW had no significant effects on the blood routine indicators, fasting blood glucose and the liver function index. The serum triglyceride level of rats in HRW group was significantly elevated (P<0.05), but there were no significant differences in cholesterol, total bile acid and uric acid between two groups. HRW had no significant effects on the cardiac function of rats. The brain weight of rats increased markedly in HRW group in comparison with the control group (P<0.05); HRW had no significant effects on body and other organs weight, water and food intake as well as faeces and urine excretions. We observed the long-term effects of HRW intervention, which is of basic research value and clinical significance. |