| 酪氨酸蛋白激酶受体c-Met及靶点药物研究进展 |
| |
| 引用本文： | 苏传铃,王斌,罗红宇,曲有乐.酪氨酸蛋白激酶受体c-Met及靶点药物研究进展[J].浙江水产学院学报,2010(3):273-278. |
| |
| 作者姓名： | 苏传铃 王斌 罗红宇 曲有乐 |
| |
| 作者单位： | [1]浙江海洋学院食品与药学学院,浙江舟山316004 [2]佳木斯大学药学院,黑龙江佳木斯154007 |
| |
| 基金项目： | 浙江省自然科学基金（Y2080579;Y2090678）; 浙江海洋学院校级课题（21135030107;11132100409） |
| |
| 摘 要： | 酪氨酸激酶受体c-Met在细胞的代谢、分化以及死亡细胞的信号传导过程中起着重要的作用,其与配体结合,可活化其信号通路,参与胚胎发育、组织损伤修复以及肿瘤的发生和发展。因而,以酪氨酸激酶受体c-Met为靶点的抗肿瘤药物已经成为肿瘤研究中十分活跃的领域,为抗肿瘤治疗提供了新方法。
|
| 关 键 词： | 受体酪氨酸激酶 c-Met 靶点药物 |
Research Progress on the Receptor Tyrosine Protein Kinase and Targeted Drugs |
| |
| Affiliation: | SU Chuan-ling,WANG Bin,LUO Hong-yu,et al(1.School of Food and Pharmacy of Zhejiang Ocean University,Zhoushan 316000;2.Medicine College,Jiamusi University,Jiamusi 154007,China) |
| |
| Abstract: | The c-Met oncogene,encoding the receptor tyrosine kinase,plays an important role in the process of cellular metabolism,differentiation and signal transduction of cell death.HGF combine c-Met can induce activation of a series of signal pathway and stimulate embryonic development,repair tissue injury and development of tumor.Thus,anticancer drugs of therapeutic target of c-Met has become very active in the cancer research field and provides a new approach for anti-tumor therapy. |
| |
| Keywords: | receptor tyrosine kinase c-Met targeted drug |
| 本文献已被 维普 等数据库收录！ |
|
