| 兔双侧下颌骨牵张成骨实验动物模型的建立 |
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| 引用本文： | 魏奉才,张东,刘少华,孙善珍.兔双侧下颌骨牵张成骨实验动物模型的建立[J].上海口腔医学,2004,13(6):502-505. |
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| 作者姓名： | 魏奉才 张东 刘少华 孙善珍 |
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| 作者单位： | 1. 山东大学齐鲁医院,口腔颌面外科,山东,济南,250012
2. 山东大学口腔医学院,山东,济南,250012 |
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| 基金项目： | 国家自然科学基金(30271349)，山东省自然科学基金(Y20001C024) |
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| 摘 要： | 目的:建立兔双侧下颌骨牵张成骨实验动物模型。方法:选用16只成年雄性新西兰大白兔,随机分为4组,每组4只。在双侧下颌骨第一前磨牙前方无牙区行骨切开术,用自制牵张器固定。经过7d潜伏期,以每次0.5mm的速度牵张,每天2次,连续7d。分别在潜伏期末、牵张结束、固定期第14天、第28天处死动物,切取标本行X线和组织学观察。结果:全部动物的下颌骨被成功延长,牵张间隙逐渐被新生骨组织充填。结论:该方法建立的动物模型具有可行性和可重复性。
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| 关 键 词： | 牵张成骨 下颌骨 动物模型 兔 |
| 文章编号： | 1006-7248(2004)06-0502-04 |
| 修稿时间： | 2003年12月22 |
The establishment of an animal model of bilateral mandibular distraction osteogenesis in rabbits |
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| WEI Feng-cai,ZHANG Dong,LIU Shao-hua,SUN Shan-zhen..The establishment of an animal model of bilateral mandibular distraction osteogenesis in rabbits[J].Shanghai Journal of Stomatology,2004,13(6):502-505. |
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| Authors: | WEI Feng-cai ZHANG Dong LIU Shao-hua SUN Shan-zhen |
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| Affiliation: | Department of Oral and Maxillofacial Surgery, Qilu Hospital, Shandong University, Jinan 250012, China. |
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| Abstract: | PURPOSE: To establish an animal model of bilateral mandibular distraction osteogenesis in rabbits. METHODS: 16 adult male white New Zealand rabbits were divided into 4 groups randomly, 4 in each group. Osteotomy was performed on mandible bilaterally before the first premolar. Bone stumps were repositioned and fixed with distractors. After 7 days of latency period, distraction was initiated at a rate of 1mm/d for 7 days. Then distractors were held in place for days. Animals were killed at different time points, and specimens were taken for X-ray and histology examination. RESULTS: The mandibles were lengthened successfully. The distraction gaps were filled with regenerated bone tissue. CONCLUSION: The method in this study is practicable and repeatable which could be used to establish an animal model of mandibular distraction osteogenesis in rabbits. |
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| Keywords: | Distraction osteogenesis Mandible Animal model Rabbit |
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