血清超敏C反应蛋白与尿碘水平联合预测先兆流产患者保胎结局的研究

目的 观察血清超敏C反应蛋白(hs-CRP)与尿碘水平联合对先兆流产患者保胎结局的预测效能.方法 前瞻性选取海南医学院第二附属医院2018年1月至2020年1月收治的112例先兆流产患者作为研究对象,根据保胎结局将患者分为保胎失败组(n=20)与保胎成功组(n=92).检测两组入院时各主要指标甲状腺功能相关指标、血清...

The combination of serum hs-CRP and urinary iodine level in predicting the outcome of fetal protection in patients with threatened abortion

Objective To observe the predictive efficiency of the combination of serum high sensitivity C-reactive protein(hs-CRP) and urinary iodine level on the outcome of fetal protection in patients with threatened abortion. Methods 112 patients with threatened abortion admitted to the Second Affiliated Hospital of Hainan Medical University from January 2018 to January 2020 were prospectively selected, and divided into failure group(n=20) and success group(n=92) according to the outcome of fetal protection. The main indexes thyroid function related indexes, serum progesterone(P), β-human chorionic gonadotropin(β-HCG), hs-CRP, urinary iodine levels] were detected in the two groups at admission, and the relationship between the main indexes and the failure outcome of threatened abortion was tested by Logistic regression analysis. The predictive efficacy of serum hs-CRP and urinary iodine level on the outcome of threatened abortion was analyzed. Results The levels of P and β-HCG in the failure group were lower than those in the success group, the level of hs-CRP was higher than that in the success group, and the proportion of thyroid dysfunction and urinary iodine in the failure group was higher than that in the success group(P<0.05). Logistic regression analysis showed that thyroid dysfunction, upregulation of hs-CRP and abnormal urinary iodine level were risk factors for the success outcome of threatened abortion(OR>1, P<0.05). The up-regulation of P and β-HCG expression was a protective factor of fetal success outcome in threatened abortion patients(OR<1, P<0.05). The results of receiver operating characteristic(ROC) curve showed that the AUC of hs-CRP, urinary iodine levels and the combination of hs-CRP and iodine levels in threatened abortion patients were all>0.70, which had certain predictive value. Conclusions Patients with threatened abortion have a certain risk of failure of fetal protection, which is closely related to thyroid dysfunction, P, β-HCG, hs-CRP and urinary iodine levels, the combination of serum hs-CRP and urinary iodine level has certain predictive efficiency for the failure of fetal protection.