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An antioxidant resveratrol significantly enhanced replication of hepatitis C virus |
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| Authors: | Mitsuyasu Nakamura Hidetsugu Saito Masanori Ikeda Ryota Hokari Nobuyuki Kato Toshifumi Hibi Soichiro Miura |
| Affiliation: | 1. Department of Internal Medicine 2,National Defense Medical Collage,3-2 Namiki,Tokorozawa,Saitama 3598513,Japan;Department of Internal Medicine,School of Medicine,Keio University,35 Shinanomachi,Shinju 2. Department of Internal Medicine,School of Medicine,Keio University,35 Shinanomachi,Shinjuku-ku,Tokyo 1608582,Japan 3. Department of Molecular Biology,Okayama University Graduate School of Medicine and Dentistry,2-5-1 Shikada-cho,Okayama 7008558,Japan 4. Department of Internal Medicine 2,National Defense Medical Collage,3-2 Namiki,Tokorozawa,Saitama 3598513,Japan |
| Abstract: | AIM:To elucidate the effect of antioxidants,resveratrol (RVT)and astaxanthin(AXN),on hepatitis C virus(HCV) replication. METHODS:We investigated the effect of recent popular antioxidant supplements on replication of the HCV replicon system OR6.RVT is a strong antioxidant and a kind of polyphenol that inhibits replication of various viruses.AXN is also a strong antioxidant.The replication of HCV RNA was assessed by the luciferase reporter assay.An additive effect of antioxidants on antiviral effects of inter... |
| Keywords: | Replicon system Luciferase assay Ribavirin Interferon Polyphenol Astaxanthin |
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