乳腺肿块超声造影增强强度与病理微血管密度的相关性

目的 研究声诺维超声造影对乳腺肿块增强强度与病理微血管密度(MVD)的相关性.方法 应用超声造影技术观察38例乳腺肿块微血管灌注情况,计算机定量测量肿块增强强度,对比良恶性肿瘤的造影强度特征,术后标本进行抗Ⅷ因子免疫组化染色,测量MVD.结果 乳腺肿块超声造影增强强度与病理MVD有较好的相关性(r=0.802,P＜0.005),造影强度与MVD恶性组均大于良性组.结论 声诺维超声造影有助于鉴别诊断乳腺良恶性肿瘤及评估乳腺癌的预后.

Correlation between contrast enhanced ultrasound intensity and pathologic microvessel density of breast masses

OObjective　To determine the relationship between contrast enhanced ultrasound (Sonovue) intensity and pathologic microvessel density(MVD) of breast masses. Methods　38 patients with breast masses were examined by contrast enhanced ultrasound. Computer-assisted analyzed intensity of breast masses and compared benign with malignant in contrast enhanced intensity. Microvessel density(MVD) was measured in surgical specimens after immunohistochemical staining using anti-factor Ⅷ. Results　These studies showed a good correlation between contrast enhanced ultrasound intensity of breast masses and pathologic microvessel density (r =0.802, P <0.005). Both intensity and density of malignant group were higher than that of benign group. Conclusion　Sonovue has a potential ability for differentiating breast masses and predicting breast cancer prognosis.