| 2-氨基-4-苯基噻唑的合成研究 |
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| 引用本文： | 曾振芳,韦友欢,黄秋婵.2-氨基-4-苯基噻唑的合成研究[J].广东化工,2014(1):28-28,41. |
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| 作者姓名： | 曾振芳 韦友欢 黄秋婵 |
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| 作者单位： | 广西民族师范学院化学与生物工程系,广西崇左532200 |
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| 基金项目： | 广西民族师范学院科研基金资助项目（2012XYYB001）;广西高校优秀人才资助计划（RC2007043） |
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| 摘 要： | 以α-溴代苯乙酮和硫脲为原料,正丙醇为溶剂,制得2-氨基-4-苯基噻唑,通过元素分析、红外光谱、1H NMR和MS确定化合物的结构。运用正交实验筛选出最佳工艺条件:反应时间为6 h,温度为97℃(回流),α-溴代苯乙酮和硫脲摩尔比为1:1.10,2-氨基-4-苯基噻唑的产率可达97%。该方法具有安全,易控制,操作简便,后处理简单等优点,适合工业化生产。
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| 关 键 词： | -氨基--苯基噻唑 合成 硫脲 正交实验 |
Study on Synthesis of 2-amino-4-phenylthiazole |
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| Zeng Zhenfang,Wei Youhuan＊,Huang Qiuchan.Study on Synthesis of 2-amino-4-phenylthiazole[J].Guangdong Chemical Industry,2014(1):28-28,41. |
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| Authors: | Zeng Zhenfang Wei Youhuan＊ Huang Qiuchan |
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| Affiliation: | (Department of Chemistry and Biological Engineering, Guangxi Normal University for Nationalities, Chongzuo 532200, China) |
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| Abstract: | In the paper, 2-amino-4-phenylthiazole was synthesized by reaction of α-bromoacetophenone and thiourea with 1-propanol as solvent, its structure has been determined by elemental analysis, IR, 1H NMR and MS. The optimum condition which was selected by orthogonal experiments is at 97 ℃（reflux） for 6 h, the ratio of α-bromoacetophenone and thiourea was 1：1.10（mol）, and the yield reached 97 %. This method has the characteristics of safety, easy control and simple operation. It has valuable for industrial applied. |
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| Keywords: | 2-amino-4-phenylthiazole synthesis thiourea orthogonal experiments |
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