以脑安滴丸为示范的偏头痛中成药临床适应症状群研究

目的]研究脑安滴丸治疗偏头痛的临床适应症状群,探讨中成药适应症状群的研究方法。方法]采用观察性研究的方法,纳入394例患者,治疗4周后,对一般情况、疾病史及全身四诊信息进行评价,应用Logistic回归分析方法,研究脑安滴丸治疗偏头痛的中成药临床适应症状群。结果]具备以下特征有效性相对较好:偏头痛伴纳差;具备以下特征有效性相对较低:内向型性格、劳累后加重、中午头痛发作、少腹胀满窜痛。结论]中成药临床适应症状群是以中医病机为内涵,一般情况、中医症状及西医学症状为表现的概念,可以准确判断偏头痛的中成药适应症状群及非症状群,对于中成药的合理使用具有指导意义。

Study on clinical adaptation symptoms of Chinese patent medicine for migraine with Nao'an Dripping Pill as demonstration

Objective] To study the clinical adaptation syndrome of Nao''an dropping pill in the treatment of migraine,and to explore the research methods of Chinese patent medicine adaptation syndrome group.Methods] There were 394 patients were enrolled in the study by observational study. After 4 weeks of treatment,the general condition,disease history and systemic diagnosis information were evaluated. Logistic regression analysis was used to study the treatment of migraine with Nao''an dropping pill. The drug is clinically adapted to the symptom group.Results] Relatively good when it has the following characteristics:migraine with poor appetite;the following characteristics are relatively low:increased after exertion,noon headache,less abdominal distension and fullness.Conclusion] The clinical adaptation syndrome of Chinese patent medicines is based on the pathogenesis of traditional Chinese medicine. The general situation,traditional Chinese medicine (TCM) symptoms and modern medical symptoms are the expressions of performance. It can accurately determine the symptomatic group and the contraindication symptom group of migraine,which is of guiding significance for the rational use of proprietary Chinese medicine.