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宫颈癌细胞接种后小鼠淋巴组织的免疫形态学研究
引用本文:李文林,温淦昇.宫颈癌细胞接种后小鼠淋巴组织的免疫形态学研究[J].江西医学院学报,1993(1).
作者姓名:李文林  温淦昇
作者单位:江西医学院病理生理学教研室,江西医学院病理生理学教研室
摘    要:在小鼠接种小鼠宫颈未分化鳞状细胞癌14号(U_(14)细胞)后的25 d时间中,动态地观察了宿主淋巴组织的重量、组织学和组织化学变化。结果发现,5~15 d细胞免疫增强,10 d最强,20d减弱。体液免疫增强从10 d后开始并持续到实验结束,20 d反应最强。提示U_(14)细胞能诱导宿主产生免疫应答,早期以细胞免疫为主,后期以体液免疫为主。

关 键 词:子宫颈肿瘤  肿瘤细胞移植  免疫活性  组织学/方法  组织化学/方法  淋巴组织  小鼠  对比研究

Studies on Lymphoid Tissue Immunomorphology in Mice Inoculated with Uterine Cervix Carcinoma Cells
Li Welin Wen Gansheng.Studies on Lymphoid Tissue Immunomorphology in Mice Inoculated with Uterine Cervix Carcinoma Cells[J].Acta Academiae Medicinae Jiangxi,1993(1).
Authors:Li Welin Wen Gansheng
Abstract:In this paper, changes of weight, histology and histochemistry in lymphoid tissue of mice inoculated with mouse uterine cervix carcinoma No. 14 (U_14) were monitored during a 25-day time course. Increased cellular immunity was present from day 5 onwards and presisted up to the 15th day of tumor growth,being maximal on day 10 and declining from day 20 onwards. An increase of the humoral immunity was observed from day 10 until the end of the time course, being maximal on day 20. These results suggest that U_14 cells, in tumor-bearing mice, could induce immune responses in which cellular immunity predominates during the early stages of tumor growth while humoral immunity predominates during the later stages of tumor growth.
Keywords:cervix neoplasm  tumor cell transplantation  immune activity  histology/method  histocytochemistry/method  lymphoid tissue  mice  comparative study
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