Triple check for antigen specificity of B cells during germinal centre reactions |
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Authors: | E Lindhout G Koopman ST Pals C de Groot |
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Affiliation: | Dept of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, The Netherlands. C.degroot@amc.uva.nl |
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Abstract: | Somatic hypermutation of the immunoglobulin variable genes during germinal reactions might permit the expansion of B-cell clones with unwanted (e.g. autoreactive) specificity. Here, Ernst Lindhout and colleagues propose three antigen-specific checkpoints that ensure the appropriate antigen specificity of activated B cells is maintained by regulating the activation, selection and further differentiation of B cells. |
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