斯奇康治疗小儿慢性腹泻疗效与T淋巴细胞亚群变化的关系

目的:研究斯奇康治疗慢性腹泻患儿的疗效及与T淋巴细胞亚群变化的关系。方法:对30例慢性腹泻患儿,用斯奇康注射液治疗6周,观察病情变化。同时治疗前后分别测定患儿血清CD3、CD4、CD8及CD4/CD8。来自门诊保健的同龄正常婴幼儿25例为对照组。结果:总有效率达93.34%。慢性腹泻组治疗前CD3、CD4、CD4/CD8降低,CD8升高,与斯奇康治疗后、对照组相比,差异无有统计学意义(P<0.05)。慢性腹泻组治疗后与正常对照组相比CD3、CD4、CD8、CD4/CD8差异无统计学意义(P>0.05)。结论:慢性腹泻患儿存在有细胞免疫缺陷;斯奇康可有效改善慢性腹泻患儿T细胞亚群状况,对提高患儿整体免疫功能水平具有重要意义。

Relationship between variation of T lymph -cell subpopulation and effect of BCG polyose nucleic acid in treating children's chronic diarrhea

Objective:To evaluate the effect of BCG polyose nucleic acid (BCG-PSN) and the relationship with variation of T Lymph-cell Subpopulation in children with chronic diarrhea.Methods:30 cases of chronic diarrhea of chirldren were treated with BCG-PSN for 6 weeks.Observing the clinical effects,measuring CD3,CD4,CD8 and CD4/CD8 of serum in chronic diarrhea of children before and after treatment respectively.25 cases normal infants of the same age from healthcare outpatient are regarded as control group.Results:The total effective rate was 93.33%.Before treatment with BCG-PSN,it was found that the value of CD3,CD4 and CD4/CD8 in treatment group were significantly lower and CD8 significantly greater than that after treatment and that in control group (P<0.05).While there was no significant differences of CD3,CD4,CD8 and CD4/CD8 in treatment group after treatment and control group (P>0.05).Conclusion:The result indicates that there is cellular immune defect and BCG-PSN contributes to elevate the whole immunologic function by improving the level of T Lymph-cell Subpopulation in children with chronic diarrhea.