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| 特应性皮炎患儿血清IL-18、sFas和sFasL测定的意义 | |
| 引用本文： | 王丹,陈秋霞,孟琼,陈铭珍,曹军.特应性皮炎患儿血清IL-18、sFas和sFasL测定的意义[J].右江医学,2004,32(3):201-202. |
| 作者姓名： | 王丹 陈秋霞 孟琼 陈铭珍 曹军 |
| 作者单位： | 1. 广东医学院附属医院,皮肤科,广东湛江,524001 2. 广东医学院附属医院,儿科,广东湛江,524001 3. 广东医学院附属医院,病理科,广东湛江,524001 |
| 摘 要： | 目的 探讨IL -18、sFas和sFasL在特应性皮炎 (AD)发生发展中的作用。方法 采用固相酶联免疫分析 (ELISA)法检测 62例AD患儿和 2 5例正常儿童血清中IL -18、sFas和sFasL的含量。结果 AD患儿血清中的IL -18、sFas和sFasL水平与正常对照组比较有明显增高 (P <0 .0 1) ,且AD患儿血清中的IL -18增高与sFas水平增高呈正相关 (r =0 .472 ,P <0 .0 1)。结论 IL -18、sFas与sFasL均参与AD免疫发病过程 ,IL -18、sFas的血清水平检测有助于了解疾病的活动性、判断病情及监测治疗效果。 |
| 关 键 词： | 特应性皮炎 IL-18 sFas sFasL 固相酶联免疫分析法 |
| 文章编号： | 1003-1383(2004)03-0201-02 |
| 修稿时间： | 2004年5月8日 |
Significance of detecting serum IL-18,sFas and sFasL level in patients with atopic dermatitis |
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| WANG Dan,MENG Qiong,CHEN Qiu-xia,CHEN Ming-zhen,CAO Jun Affiliated Hospital Of Guangdong Medical College,Zhanjiang,Guangdong,P R China.Significance of detecting serum IL-18,sFas and sFasL level in patients with atopic dermatitis[J].Youjiang Medical Journal,2004,32(3):201-202. | |
| Authors: | WANG Dan MENG Qiong CHEN Qiu-xia CHEN Ming-zhen CAO Jun Affiliated Hospital Of Guangdong Medical College Zhanjiang Guangdong P R China |
| Affiliation: | WANG Dan,MENG Qiong,CHEN Qiu-xia,CHEN Ming-zhen,CAO Jun Affiliated Hospital Of Guangdong Medical College,Zhanjiang,524001,Guangdong,P R China |
| Abstract: | Objective To investigate the effect of IL-18,sFas and sFasL in patient with atopic dermatitis(AD). Methods Serum levels of IL-18, sFas and sFasL in 62 children with AD and 25 normal children were measured by enzyme-linked immunoadsorbent assay (ELISA).Results IL-18、 sFas and sFasL in children with AD were increased significantly when compared to that of normal controls (P<0.01).The step-up of IL-18 in AD was positive correlation with sFas(r=0.472,P<0.01).Conclusion IL-18、 sFas and sFasL may be involved in the Immunopathogenesis of AD. Measuring the Serum levels of IL-18, sFas and sFasL may be useful in evaluating the activity, the clinical pattern, and the monitoring the clinical effect of AD therapy. |
| Keywords: | Atopic dermatitis IL-18 sFas sFasL Enzyme-linked immunoadsorbent assay |
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