局部亚低温治疗急性脑出血的临床研究

目的观察局部亚低温治疗对急性脑出血患者颅内血肿、周围水肿及神经功能缺损程度的影响。方法将80例急性脑出血患者随机分为对照组和治疗组，每组40例，对照组为单纯的药物治疗，治疗组在药物治疗的基础上同时加用局部亚低温治疗，分别于入院当天、治疗后第1、7、14天计算颅内血肿体积和周围水肿的体积，同时进行神经功能缺损的评分。结果①与对照组比较，治疗组治疗后第7、14天神经功能评分明显降低，差异有统计学意义（P〈0．01）。②治疗组治疗后第1、7、14天血肿体积和脑水肿体积与对照组比较差异有统计学意义（P〈0．01）。结论局部亚低温治疗能明显减轻急性脑出血患者的脑水肿，干预脑出血早期继续出血，减轻神经功能缺损的程度，提高临床疗效并改善预后。

Clinical study of local mild hypothermia on treatment of acute intracerebral hemorrhage

Abstract：Objective To observe the influence of local mild hypothermia on hematoma,peripheral edema and the degree of neurological impairment of patients with acute cerebral hemorrhage. Methods All eighty patients with acute cerebral hemorrhage were randomly divided into control group （40 cases ） and therapy group （40 cases ） , the control group received the routine treatment, while the therapy group received additional local mild hypothermia therapy based on the routine treatment. In both groups, hematoma volume, peripheral edema, neurological deficit score were measured in the day of ad- mission, 1,7 and 14 days after treatment, respectively. Results （~）There were statistically significant difference of neuro- logical function score in the two groups of 7 and 14 days after treatment（ P 〈 0.01 ）. （~）There were statistically significant difference of hematoma volume and brain edema volume in the two groups of 1,7 and 14 days after treatment（ P 〈 0.01 ）. Conclusion Mild hypothermia therapy can significantly reduce cerebral edema,intervene early continued bleeding, miti- gate the degree of neurological deficit, improve the clinical efficacy and improve the prognosis.