Biomimetic properties of an injectable chitosan/nano-hydroxyapatite/collagen composite |
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Authors: | Zhi HuangQingling Feng Bo YuSongjian Li |
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Affiliation: | a Laboratory of Advanced Materials, Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, Chinab Department of Orthopedics, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, China |
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Abstract: | To meet the challenges of designing an injectable scaffold and regenerating bone with complex three-dimensional (3D) structures, a biomimetic and injectable hydrogel scaffold based on nano-hydroxyapatite (HA), collagen (Col) and chitosan (Chi) is synthesized. The chitosan/nano-hydroxyapatite/collagen (Chi/HA/Col) solution rapidly forms a stable gel at body temperature. It shows some features of natural bone both in main composition and microstructure. The Chi/HA/Col system can be expected as a candidate for workable systemic minimally invasive scaffolds with surface properties similar to physiological bone based on scanning electron microscopic (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR) results. |
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Keywords: | Biomimetic Injectable Hydrogel In situ Bone |
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