氟西汀合并抗精神病药物治疗具有强迫症状的精神分裂症的疗效分析

目的 探讨抗精神病药物合并氟丁汀治疗具有强迫症状的精神分裂症的临床疗效。方法 对原用抗精神病药物治疗的以强迫症状为主的36例精神分裂症患者随机分成两组,一组加用氟西汀(研究组),另一组仍用原抗精神病药物(对照组)治疗8周,用PANSS、Y-BOCS、TESS评定两组精神症状变化和副反应,用t检验对照分析。结果 研究组的PANSS、Y-BOCS总分比对照组明显下降,且有显著性差异(P<0.01)。结论 强迫症状明显的精神分裂症患者,采用抗精神病药物合并氟西汀治疗,可提高疗效。

An efficacy analysis of fluoxetine added to neuroleptics for obsessive-complusive symptoms in schizophrenia

Objective To explore the effect of fluoxetine added to neuroleptics in the treatment of obsessive - com-plusive symptoms with schizophrenia. Method 36 cases with obsessive - complusive symptoms in schizophrenia were randomly divided into two groups treated respectively, such as fluoxetine added to neuroleptics and neuroleptics alone for 8 weeks. The efficacy and side effects were assessed with PANSS,Y - BOCS and TESS. Results After fluoxetine augmentation , the total scores of PANSS and Y - BOCS were significandy decreased( P < 0. 01) after 8 weeks treatment. Conclusion Combined fluoxetine with neuroleptics was effective treatment for obsessive - complusive symptoms with schizophrenia.