| High circulating D-dimers are associated with ascites and hepatocellular carcinoma in liver cirrhosis |
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| 作者姓名： | Spadaro A Tortorella V Morace C Fortiguerra A Composto P Bonfiglio C Alibrandi A Luigiano C De Caro G Ajello A Ferrau O Freni MA |
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| 作者单位： | Department of Medicine and Pharmacology University Hospital Messina 98125 Italy，Department of Medicine and Pharmacology University Hospital Messina 98125 Italy，Department of Medicine and Pharmacology University Hospital Messina 98125 Italy，Department of Medicine and Pharmacology University Hospital Messina 98125 Italy，Department of Medicine and Pharmacology University Hospital Messina 98125 Italy，Department of Medicine and Pharmacology University Hospital Messina 98125 Italy，Department of Statistics University oMessina Messina 98125 Italy，Department of Medicine and Pharmacology University Hospital Messina 98125 Italy，Department of Medicine and Pharmacology University Hospital Messina 98125 Italy，Department of Medicine and Pharmacology University Hospital Messina 98125 Italy，Department of Medicine and Pharmacology University Hospital Messina 98125 Italy，Department of Medicine and Pharmacology University Hospital Messina 98125 Italy |
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| 基金项目： | Dr. Maria Concertina Tripoli for important contribution in the revision of the English language. |
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| 摘 要： | AIM： To measure plasma D-dimer levels in cirrhotic patients with and without ascites, assessing the effect of ascites resolution in D-dimer concentration. METHODS： Seventy consecutive cirrhotic patients （M = 44, F = 26, mean age 65 years, SD ± 13）, observed from October 2005 to March 2006 were enrolled. Circulating D-dimer levels were measured using a latex-enhanced, immunoturbidimetric test. In patients with ascites （n = 42） the test was repeated after ascites resolution. RESULTS： Ascites was present in 42 patients （group A） and absent in 28 （group B）. Group A patients had more advanced liver disease. Hepatocellular carcinoma （HCC） was diagnosed in 14 patients and was more frequent in group B. Above normal range D-dimers were found in 45/70 patients. High D-dimers were more frequent in group A than in group B （P = 0.001）. High D-dimers were associated with presence of HCC （P = 0.048） only in group B. After ascites resolution, obtained in all patients, mean D-dimer values decreased in those 34 patients with high basal levels （P = 0.007）, returning to normal in 17. CONCLUSION： In patients with liver cirrhosis, ascites and HCC are the main factors associated with increased fibrinolytic activity.
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| 关 键 词： | 肝细胞癌 肝硬化 腹水 D-二聚物 |
| 收稿时间： | 2007 Aug 29 |
High circulating D-dimers are associated with ascites and hepatocellular carcinoma in liver cirrhosis |
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| Spadaro A,Tortorella V,Morace C,Fortiguerra A,Composto P,Bonfiglio C,Alibrandi A,Luigiano C,De Caro G,Ajello A,Ferrau O,Freni MA.High circulating D-dimers are associated with ascites and hepatocellular carcinoma in liver cirrhosis[J].World Journal of Gastroenterology,2008,14(10):1549-1552. |
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| Authors: | Spadaro Aldo Tortorella Vincenza Morace Carmela Fortiguerra Agostino Composto Paola Bonfiglio Caterina Alibrandi Angela Luigiano Carmelo De Caro Giuseppe Ajello Antonino Ferrau Oscar Freni Maria-Antonietta |
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| Affiliation: | 1. Department of Medicine and Pharmacology University Hospital,Messina 98125,Italy
2. Department of Statistics,University of Messina,Messina 98125,Italy |
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| Abstract: | AIM:To measure plasma D-dimer levels in cirrhotic patients with and without ascites,assessing the effect of ascites resolution in D-dimer concentration.METHODS:Seventy consecutive cirrhotic patients(M=44,F=26,mean age 65 years,SD±13),observed from OdDber 2005 to March 2006 were enrolled.Circulating D-dimer Ievels were measured using a latex-enhanced,immunoturbidimetric test.In patients with ascites(,7=42)the test was repeated after ascites resolution.RESULTS:Ascites was present in 42 patients(group A)and absent in 28(group B).Group A patients had more advanced Iiver disease.Hepatocellular carcinoma(HCC)was diagnosed in 14 patients and was more frequent in group B.Above normaI range D-dimers were found in 45/70 patients.High D-dimers were more frequent in group A than in group B(P=0.001).High D-dimers were associated with presence of HCC(P=0.048)only in group B.Afber ascites resolution,obtained in all patienIs,mean D-dimer values decreased in those 34 patients with high basal levels(P=0.007),returning to normal in 17.CONCLUSION:In patients with Iiver cirrhosis,ascites and HCC are the main factors associated with increased fibrinolytic activiby. |
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| Keywords: | D-dimers Liver cirrhosis Ascites Hepatocellular carcinoma Hyperfibrinolysis liver cirrhosis hepatocellular carcinoma ascites associated circulating factors increased normal values presence High Above range frequent Hepatocellular advanced Iiver disease group present |
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